Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 5/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.51 |
| ▸ | PADI6 | Q6TGC4 | 1/20 | 0.51 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.51 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10026328 | 0.91 | PDE4A (0.50) | BMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10026322 | 0.91 | PDE4A (0.51) | BMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2703295 | 0.90 | PDE4A (0.51) | BMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28104364 | 0.90 | PDE4A (0.49) | BMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2703298 | 0.90 | PDE4A (0.51) | BMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16124204 | 0.90 | MMP2 (0.56) | BMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27926558 | 0.89 | PDE4A (0.47) | BMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2701630 | 0.81 | PADI4 (0.73) | PDE4APDE4BPDE4CPDE4DPADI6 | |
| SCHEMBL7299650 | 0.74 | NPY5R (0.52) | NPY5RMMP2MMP9MMP14POLB | |
| SCHEMBL7297288 | 0.74 | NPY5R (0.52) | NPY5RMMP2MMP9MMP14POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969333-B2 | Therapeutic compositions and methods | THE PENN STATE RESEARCH FOUNDATION (US) | 2015-03-03 | — | — | US | disclosed |
| US-20140288059-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | THE PENN STATE RESEARCH FOUNDATION (US) | 2014-09-25 | — | — | US | disclosed |
| US-8710039-B2 | Therapeutic compositions and methods | THE PENN STATE RESEARCH FOUNDATION (US) | 2014-04-29 | — | — | US | disclosed |
| WO-2012061390-A2 | THERAPEUTIC COMPOSITIONS AND METHODS | THE PENN STATE RESEARCH FOUNDATION (US) | 2012-05-10 | — | — | WO | disclosed |
| US-20120108562-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | THE PENN STATE RESEARCH FOUNDATION (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288059-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | PADI4, PADI2, PADI3 | BMP1 3928/4885PDE4A 12/4885PDE4B 13/4885 |
| US-20120108562-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | PADI4, PADI2, PADI3 | BMP1 3928/4885PDE4A 12/4885PDE4B 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.