Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | PADI6 | Q6TGC4 | 1/20 | 0.50 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.50 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.50 |
| ▸ | BMP1 | P13497 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27926558 | 0.94 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPADI6 | |
| SCHEMBL2703295 | 0.92 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPADI6 | |
| SCHEMBL28104364 | 0.92 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPADI6 | |
| SCHEMBL2703298 | 0.92 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPADI6 | |
| SCHEMBL2702104 | 0.91 | BMP1 (0.51) | PDE4APDE4BPDE4CPDE4DPADI6 | |
| SCHEMBL10026322 | 0.87 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPADI6 | |
| SCHEMBL16124204 | 0.86 | MMP2 (0.56) | PDE4APDE4BPDE4CPDE4DPADI6 | |
| SCHEMBL16124246 | 0.81 | PADI4 (0.72) | PDE4APDE4BPDE4CPDE4DPADI6 | |
| SCHEMBL27908420 | 0.78 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DPADI6 | |
| SCHEMBL7299650 | 0.75 | NPY5R (0.52) | POLBNPY5RMMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108562-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | THE PENN STATE RESEARCH FOUNDATION (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108562-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | PADI4, PADI2, PADI3 | PDE4A 12/4885PDE4B 13/4885PDE4C 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.