Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.53 |
| ▸ | BAD | Q92934 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1938267 | 0.94 | CES2 (0.50) | BCL2L1BADPTPN1CES2CES1 | |
| SCHEMBL4457061 | 0.84 | HPGD (0.46) | CES2CES1ALDH1A1CYP1A2HTT | |
| SCHEMBL1928398 | 0.82 | SMN1; SMN2 (0.57) | PTPN1ALDH1A1CYP1A2CYP2C9NPC1 | |
| SCHEMBL11689860 | 0.81 | BCL2L1 (0.53) | BCL2L1BADPTPN1CES2CES1 | |
| SCHEMBL204960 | 0.77 | CES2 (0.54) | BCL2L1BADPTPN1CES2CES1 | |
| SCHEMBL6726501 | 0.77 | CES2 (0.54) | BCL2L1BADPTPN1CES2CES1 | |
| SCHEMBL3364624 | 0.77 | GSK3B (0.61) | BCL2L1BADPTPN1CES2CES1 | |
| SCHEMBL4102288 | 0.77 | ALDH1A1 (0.51) | PTPN1CES2CES1ALDH1A1CYP1A2 | |
| SCHEMBL7948329 | 0.76 | CES2 (0.43) | BCL2L1BADPTPN1CES2CES1 | |
| SCHEMBL2448326 | 0.75 | CES2 (0.52) | BCL2L1BADPTPN1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030875-B2 | EIF4E inhibitors and uses thereof | PIC Therapeutics, Inc. (US) | 2024-07-09 | — | — | US | disclosed |
| EP-3846793-B1 | EIF4E INHIBITORS AND USES THEREOF | PIC THERAPEUTICS INC (US) | 2024-01-24 | — | — | EP | disclosed |
| US-20220089587-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. | 2022-03-24 | — | — | US | disclosed |
| CN-113164419-A | EIF4E inhibitors and uses thereof | 皮克医疗公司 | 2021-07-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030875-B2 | EIF4E inhibitors and uses thereof | EIF4E, EIF4EBP1, EIF4A1 | BCL2L1 2634/4885BAD 2232/4885PTPN1 2316/4885 |
| US-20220089587-A1 | EIF4E INHIBITORS AND USES THEREOF | EIF4E, EIF4EBP1, EEF2K | BCL2L1 2778/4885BAD 2453/4885PTPN1 2907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.