Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | ATR | Q13535 | 3/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27059609 | 0.99 | LRRK2 (0.42) | LRRK2IRAK4PIK3CAMTORPIM1 | |
| Hydrochloric Acid SCHEMBL27035229 | 0.98 | LRRK2 (0.41) | LRRK2IRAK4PIK3CAMTORPIM1 | |
| Bromide SCHEMBL27035319 | 0.86 | IRAK4 (0.40) | IRAK4PIM1 | |
| SCHEMBL27059667 | 0.85 | IRAK4 (0.40) | IRAK4PIM1 | |
| SCHEMBL30769759 | 0.85 | IRAK4 (0.40) | IRAK4PIM1 | |
| SCHEMBL24683415 | 0.78 | CDK9 (0.40) | IRAK4PIM1 | |
| SCHEMBL29845323 | 0.78 | CDK9 (0.40) | IRAK4PIM1 | |
| SCHEMBL29845331 | 0.78 | CDK9 (0.40) | IRAK4PIM1 | |
| Hydrochloric Acid SCHEMBL30769827 | 0.77 | CDK9 (0.40) | IRAK4PIM1 | |
| Hydrochloric Acid SCHEMBL27147682 | 0.77 | CDK9 (0.40) | IRAK4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024017977-A1 | IMIDAZOPYRIDINE COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI (FR) | 2024-01-25 | — | — | WO | disclosed |