Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | CPA1 | P15085 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27041659 | 1.00 | KCNA5 (0.45) | KCNA5CTSKSLC1A5MMEACE | |
| SCHEMBL30759455 | 0.91 | CTSK (0.42) | CTSKSLC1A5MMEACECPA1 | |
| SCHEMBL30759432 | 0.89 | KCNA5 (0.40) | KCNA5CTSK | |
| SCHEMBL27041529 | 0.82 | PTPN1 (0.40) | CTSK | |
| SCHEMBL27041503 | 0.82 | PTPN1 (0.40) | CTSK | |
| SCHEMBL27041505 | 0.81 | MMP12 (0.34) | CTSKMMP12REN | |
| SCHEMBL27041528 | 0.81 | MMP12 (0.34) | CTSKMMP12REN | |
| SCHEMBL30517407 | 0.81 | MME (0.46) | MMEACECPA1ACE2REN | |
| SCHEMBL27041653 | 0.80 | LMNA (0.44) | SLC1A5LMNAANPEPERAP2ERAP1 | |
| SCHEMBL27041657 | 0.80 | LMNA (0.44) | SLC1A5LMNAANPEPERAP2ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024020159-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | MERCK SHARP & DOHME LLC (US) | 2024-01-25 | — | — | WO | disclosed |