Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27041653 | 1.00 | LMNA (0.44) | LMNATBXAS1TDP1L3MBTL1KDM4E | |
| SCHEMBL30759455 | 0.86 | CTSK (0.42) | LMNAKMT2APKMSLC1A5MMP9 | |
| SCHEMBL30759428 | 0.86 | RIPK1 (0.39) | LMNATDP1L3MBTL1KMT2APKM | |
| SCHEMBL31754336 | 0.84 | LMNA (0.39) | LMNATDP1L3MBTL1KMT2APKM | |
| SCHEMBL30759465 | 0.81 | LMNA (0.37) | LMNATBXAS1ANPEPERAP2ERAP1 | |
| SCHEMBL27041659 | 0.80 | KCNA5 (0.45) | LMNAANPEPERAP2ERAP1SLC1A5 | |
| SCHEMBL27041655 | 0.80 | KCNA5 (0.45) | LMNAANPEPERAP2ERAP1SLC1A5 | |
| SCHEMBL30759517 | 0.78 | LMNA (0.42) | LMNATBXAS1KDM4EKMT2APKM | |
| SCHEMBL7907904 | 0.77 | ALPI (0.50) | PKMANPEP | |
| SCHEMBL31000651 | 0.76 | MME (0.50) | MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024020159-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | MERCK SHARP & DOHME LLC (US) | 2024-01-25 | — | — | WO | disclosed |