Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.50 |
| ▸ | XIAP | P98170 | 3/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27045994 | 0.93 | PTGS2 (0.42) | PTGS2XIAPADORA2AADORA1ALDH1A1 | |
| SCHEMBL27045996 | 0.91 | PTGS2 (0.41) | PTGS2XIAPADORA2AADORA1ALDH1A1 | |
| SCHEMBL27049052 | 0.89 | PTGS2 (0.51) | PTGS2XIAPADORA2AADORA1ALDH1A1 | |
| SCHEMBL27045847 | 0.87 | PTGS2 (0.47) | PTGS2XIAPADORA2AADORA1ALDH1A1 | |
| SCHEMBL27049956 | 0.86 | PTGS2 (0.41) | PTGS2XIAPADORA2AADORA1ALDH1A1 | |
| SCHEMBL27045351 | 0.83 | HPGDS (0.35) | PTGS2ADORA2AADORA1ALDH1A1KDM4E | |
| SCHEMBL27046359 | 0.82 | PTGS2 (0.50) | PTGS2XIAPADORA2AADORA1ALDH1A1 | |
| SCHEMBL27046008 | 0.82 | PTGS2 (0.50) | PTGS2XIAPADORA2AADORA1ALDH1A1 | |
| SCHEMBL27045984 | 0.81 | PTGS2 (0.56) | PTGS2XIAPADORA2AADORA1ALDH1A1 | |
| SCHEMBL27045445 | 0.81 | PTGS2 (0.56) | PTGS2XIAPALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3846793-B1 | EIF4E INHIBITORS AND USES THEREOF | PIC THERAPEUTICS INC (US) | 2024-01-24 | — | — | EP | disclosed |