Acetoacetic Acid

Acetoacetic Acid

SCHEMBL2705262

CC(=O)CC(=O)O.CC(=O)CC(=O)O.CC(CO)CO

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.41
KDM6B O15054 1/20 0.41
KDM5C P41229 1/20 0.41
EGLN1 Q9GZT9 1/20 0.41
PHF8 Q9UPP1 1/20 0.41
KDM2A Q9Y2K7 1/20 0.41
LDHA P00338 1/20 0.38
SRR Q9GZT4 1/20 0.38
ALDH1A1 P00352 3/20 0.36
TDP1 Q9NUW8 2/20 0.36
LMNA P02545 2/20 0.36
SLC15A2 Q16348 1/20 0.36
TSHR P16473 2/20 0.35
MGAM O43451 1/20 0.35
GAA P10253 1/20 0.35
SI P14410 1/20 0.35
MGAM2 Q2M2H8 1/20 0.35
TGFBR1 P36897 1/20 0.33
MAPT P10636 1/20 0.32
PTGS2 P35354 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetoacetic Acid SCHEMBL17746189 0.87 TSHR (0.47) KDM4EKDM6BKDM5CEGLN1PHF8
Malonic Acid SCHEMBL30288586 0.87 LDHA (0.53) LDHASRRALDH1A1TDP1LMNA
Acetoacetic Acid SCHEMBL5797078 0.85 TDP1 (0.50) KDM4EKDM6BKDM5CEGLN1PHF8
Acetoacetic Acid SCHEMBL28640192 0.85 TDP1 (0.50) KDM4EKDM6BKDM5CEGLN1PHF8
Acetoacetic Acid SCHEMBL1058961 0.85 TDP1 (0.50) KDM4EKDM6BKDM5CEGLN1PHF8
Acetoacetic Acid SCHEMBL9278066 0.84 KDM4E (0.48) KDM4EKDM6BKDM5CEGLN1PHF8
Acetoacetic Acid SCHEMBL8760340 0.81 KDM4E (0.46) KDM4EKDM6BKDM5CEGLN1PHF8
Acetoacetic Acid SCHEMBL6837513 0.81 KDM4E (0.46) KDM4EKDM6BKDM5CEGLN1PHF8
Acetoacetic Acid SCHEMBL18911302 0.81 KDM4E (0.46) KDM4EKDM6BKDM5CEGLN1PHF8
Acetoacetic Acid SCHEMBL1640437 0.81 TDP1 (0.46) KDM4EKDM6BKDM5CEGLN1PHF8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12378434-B2 Curable coating compositions EASTMAN CHEMICAL COMPANY (US) 2025-08-05 US claimed
EP-4574871-A1 CURABLE POLYMER COMPOSITIONS COMPRISING ALDIMINES, POLYISOCYANATES AND COMPOUNDS WITH ACTIVATED METHYLENE GROUPS Sika Technology AG (CH) 2025-06-25 EP claimed
EP-4574867-A1 CURABLE POLYMER COMPOSITIONS CONTAINING ISOCYANATES, ALDIMINES AND COMPOUNDS HAVING ACTIVATED METHYLENE GROUPS Sika Technology AG (CH) 2025-06-25 EP claimed
CN-113166033-B Curable coating composition 伊士曼化工公司 2024-05-24 CN claimed
EP-3894386-B1 CURABLE COATING COMPOSITIONS EASTMAN CHEM CO (US) 2024-02-21 EP claimed
US-11447670-B2 Curable acetoacetylated resin compositions comprising aldehydes and certain basic catalysts EASTMAN CHEMICAL COMPANY (US) 2022-09-20 US claimed
US-20220056171-A1 Isocyanate Free Binder ARXADA AG (CH) 2022-02-24 US claimed
US-20210388229-A1 CURABLE COATING COMPOSITIONS EASTMAN CHEMICAL COMPANY (US) 2021-12-16 US claimed
EP-3909702-A1 ISOCYANATE FREE BINDER Lonza Solutions AG (CH) 2021-11-17 EP claimed
CN-113438992-A Isocyanate-free adhesives 隆萨解决方案股份公司 2021-09-24 CN claimed
CN-113166033-A Curable coating compositions 伊士曼化工公司 2021-07-23 CN claimed
US-20200181465-A1 CURABLE ACETOACETYLATED RESIN COMPOSITIONS COMPRISING ALDEHYDES AND CERTAIN BASIC CATALYSTS EASTMAN CHEMICAL COMPANY (US) 2020-06-11 US claimed
US-12378434-B2 Curable coating compositions EASTMAN CHEMICAL COMPANY (US) 2025-08-05 US disclosed
EP-4574871-A1 CURABLE POLYMER COMPOSITIONS COMPRISING ALDIMINES, POLYISOCYANATES AND COMPOUNDS WITH ACTIVATED METHYLENE GROUPS Sika Technology AG (CH) 2025-06-25 EP disclosed
EP-4574867-A1 CURABLE POLYMER COMPOSITIONS CONTAINING ISOCYANATES, ALDIMINES AND COMPOUNDS HAVING ACTIVATED METHYLENE GROUPS Sika Technology AG (CH) 2025-06-25 EP disclosed
EP-3894477-B1 CONTROLLED CURE FOR COMPOSITIONS COMPRISING ACETOACETYLATED RESINS EASTMAN CHEM CO (US) 2025-01-15 EP disclosed
EP-1593728-A2 Michael addition compositions ROHM AND HAAS COMPANY (US) 2005-11-09 EP disclosed
US-20050245721-A1 Bonding substrate, forming foams, elastomers, roofing membrane, gasket; using catalyst; laminating adhesive ROHM AND HAAS COMPANY 2005-11-03 US disclosed
US-20050081994-A1 Bonding substrates, forming foams, elastomers; laminated adhesive BECKLEY RONALD S (US) 2005-04-21 US disclosed
EP-1435383-A1 Methods of using michael addition compositions ROHM AND HAAS COMPANY (US) 2004-07-07 EP disclosed