Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | IAPP | P10997 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922567 | 0.85 | KMT2A (0.49) | ALDH1A1TSHRNPSR1CYP1A2MAPT | |
| SCHEMBL15574689 | 0.85 | KMT2A (0.49) | ALDH1A1TSHRNPSR1CYP1A2MAPT | |
| SCHEMBL27033930 | 0.82 | KMT2A (0.41) | ALDH1A1TSHRNPSR1CYP1A2MAPT | |
| SCHEMBL4772581 | 0.81 | HPGD (0.42) | ALDH1A1NPSR1CYP1A2MAPTKMT2A | |
| SCHEMBL24251808 | 0.79 | ALDH1A1 (0.48) | ALDH1A1TSHRCA1CA2CA9 | |
| SCHEMBL29756270 | 0.79 | ALDH1A1 (0.48) | ALDH1A1TSHRCA1CA2CA9 | |
| SCHEMBL29469481 | 0.78 | KMT2A (0.48) | ALDH1A1NPSR1KMT2AMEN1KDM4E | |
| SCHEMBL22660238 | 0.78 | KMT2A (0.48) | ALDH1A1NPSR1KMT2AMEN1KDM4E | |
| SCHEMBL388845 | 0.78 | NPSR1 (0.50) | ALDH1A1TSHRNPSR1CA1CA2 | |
| SCHEMBL29829085 | 0.78 | NPSR1 (0.50) | ALDH1A1TSHRNPSR1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12600723-B2 | Tetracyclic compounds as DGK inhibitors | INCYTE CORPORATION (US) | 2026-04-14 | — | — | US | disclosed |
| US-20240034734-A1 | TETRACYCLIC COMPOUNDS AS DGK INHIBITORS | INCYTE CORPORATION | 2024-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240034734-A1 | TETRACYCLIC COMPOUNDS AS DGK INHIBITORS | DGKA, DGKG, DGKI | ALDH1A1 3928/4885TSHR 3374/4885NPSR1 4801/4885 |
| US-12600723-B2 | Tetracyclic compounds as DGK inhibitors | DGKB, DGKA, NR2C2 | ALDH1A1 3817/4885TSHR 357/4885NPSR1 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.