Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927397 | 0.87 | ALDH1A1 (0.77) | DRD2SIGMAR1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL270705 | 0.87 | DRD2 (0.51) | DRD2SIGMAR1ALDH1A1SMN1; SMN2KCNH2 | |
| Ammonia Solution, Strong SCHEMBL11284383 | 0.85 | ALDH1A1 (0.75) | DRD2SIGMAR1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL11947326 | 0.82 | ADRA2C (0.61) | SIGMAR1ALDH1A1TSHRMAPTMAPK1 | |
| SCHEMBL271336 | 0.81 | DRD2 (0.64) | DRD2SIGMAR1SMN1; SMN2MAPT | |
| SCHEMBL14346827 | 0.80 | ALDH1A1 (0.64) | DRD2SIGMAR1ALDH1A1SMN1; SMN2DRD3 | |
| SCHEMBL14218788 | 0.80 | KCNH2 (0.77) | DRD2SIGMAR1KCNH2DRD3HTR7 | |
| SCHEMBL13763204 | 0.79 | KCNH2 (0.55) | DRD2SIGMAR1KCNH2DRD3HTR7 | |
| SCHEMBL12017183 | 0.79 | ALDH1A1 (0.49) | SIGMAR1ALDH1A1TSHRMAPTMAPK1 | |
| SCHEMBL13875120 | 0.78 | SIGMAR1 (0.69) | DRD2SIGMAR1ALDH1A1SMN1; SMN2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133900-B2 | Use of bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-20110269721-A1 | METHODS OF TREATING THALASSEMIA | TARGEGEN, INC. (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110212077-A1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | TARGEGEN, INC. (US) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212077-A1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | JAK2, TYK2, JAK3 | DRD2 2424/4885SIGMAR1 1178/4885ALDH1A1 3235/4885 |
| US-20110269721-A1 | METHODS OF TREATING THALASSEMIA | JAK2, STAT5A, STAT5B | DRD2 4732/4885SIGMAR1 4142/4885ALDH1A1 1825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.