SCHEMBL2709623

SCHEMBL2709623

O=C(Nc1cc(O)ccc1F)C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK1 Q15118 2/20 0.44
PDK2 Q15119 2/20 0.44
PDK3 Q15120 2/20 0.44
PDK4 Q16654 2/20 0.44
TMPRSS4 Q9NRS4 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
HTT P42858 2/20 0.40
ALDH1A1 P00352 1/20 0.40
GAA P10253 1/20 0.40
THRB P10828 1/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
MAPT P10636 2/20 0.40
KDM4E B2RXH2 1/20 0.40
RAB9A P51151 1/20 0.40
TSHR P16473 1/20 0.40
P2RX1 P51575 1/20 0.39
JAK2 O60674 1/20 0.39
TP53 P04637 1/20 0.39
KLK7 P49862 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15667865 0.84 PDK1 (0.47) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL2088279 0.81 PDK1 (0.41) PDK1PDK2PDK3PDK4TMPRSS4
SCHEMBL15998606 0.81 PDK1 (0.43) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL3441761 0.81 ALDH1A1 (0.42) PDK1PDK2PDK3PDK4TMPRSS4
SCHEMBL14515393 0.81 ALDH1A1 (0.52) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL9824176 0.81 TSHR (0.47) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL3294939 0.80 PDK1 (0.49) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL4281754 0.79 MAPT (0.43) HTTALDH1A1MEN1KMT2AMAPT
SCHEMBL6988369 0.78 CYP4F2 (0.43) PDK1PDK2PDK3PDK4TMPRSS4
SCHEMBL2452625 0.78 CYP1A2 (0.45) PDK1PDK2PDK3PDK4L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11275265-B2 Control of illumination spectra for LCD displays MOLECULED LTD. (IL) 2022-03-15 US disclosed
US-10808127-B2 Color conversion with solid matrix films and green rhodamines MOLECULED LTD. (IL) 2020-10-20 US disclosed
US-10808127-B2 Color conversion with solid matrix films and green rhodamines MOLECULED LTD. (IL) 2020-10-20 US disclosed
US-10465110-B2 Rhodamine based salts StoreDot Ltd. (IL) 2019-11-05 US disclosed
US-10465110-B2 Rhodamine based salts StoreDot Ltd. (IL) 2019-11-05 US disclosed
US-10240042-B2 Photoluminescent compounds and uses thereof StoreDot Ltd. (IL) 2019-03-26 US disclosed
US-10240042-B2 Photoluminescent compounds and uses thereof StoreDot Ltd. (IL) 2019-03-26 US disclosed
US-10227492-B2 Modifications of the sol-gel films and production processes thereof StoreDot Ltd. (IL) 2019-03-12 US disclosed
US-10227492-B2 Modifications of the sol-gel films and production processes thereof StoreDot Ltd. (IL) 2019-03-12 US disclosed
US-10100197-B2 Rhodamine derivatives dyes and uses thereof StoreDot Ltd. (IL) 2018-10-16 US disclosed
US-20180057689-A1 RHODAMINE DERIVATIVES DYES AND USES THEREOF StoreDot Ltd. (IL) 2018-03-01 US disclosed
US-20180037738-A1 COLOR CONVERSION WITH SOLID MATRIX FILMS StoreDot Ltd. (IL) 2018-02-08 US disclosed
US-20180037738-A1 COLOR CONVERSION WITH SOLID MATRIX FILMS StoreDot Ltd. (IL) 2018-02-08 US disclosed
US-20180039131-A1 CONTROL OF ILLUMINATION SPECTRA FOR LCD DISPLAYS StoreDot Ltd. (IL) 2018-02-08 US disclosed
US-20180039131-A1 CONTROL OF ILLUMINATION SPECTRA FOR LCD DISPLAYS StoreDot Ltd. (IL) 2018-02-08 US disclosed
EP-2445969-B1 NOVEL FLUORINATED RHODAMINES AS PHOTOSTABLE FLUORESCENT DYES FOR LABELLING AND IMAGING TECHNIQUES MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V (DE) 2014-08-27 EP disclosed
US-8735444-B2 Fluorinated rhodamines as photostable fluorescent dyes for labelling and imaging techniques MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (DE) 2014-05-27 US disclosed
US-20120135459-A1 NOVEL FLUORINATED RHODAMINES AS PHOTOSTABLE FLUORESCENT DYES FOR LABELLING AND IMAGING TECHNIQUES MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (DE) 2012-05-31 US disclosed
EP-2445969-A1 NOVEL FLUORINATED RHODAMINES AS PHOTOSTABLE FLUORESCENT DYES FOR LABELLING AND IMAGING TECHNIQUES Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2012-05-02 EP disclosed
WO-2010149190-A1 NOVEL FLUORINATED RHODAMINES AS PHOTOSTABLE FLUORESCENT DYES FOR LABELLING AND IMAGING TECHNIQUES MAX-PLANCK-GESELLSCHAFT ZUR (DE) 2010-12-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120135459-A1 NOVEL FLUORINATED RHODAMINES AS PHOTOSTABLE FLUORESCENT DYES FOR LABELLING AND IMAGING TECHNIQUES SNRPD1, SRSF6, DRD1 PDK1 4200/4885PDK2 3705/4885PDK3 3078/4885
US-10240042-B2 Photoluminescent compounds and uses thereof MAPRE2, TYR, IK PDK1 3815/4885PDK2 2248/4885PDK3 2603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.