Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | PKM | P14618 | 3/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.53 |
| ▸ | IL1RN | P18510 | 1/20 | 0.53 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22778806 | 0.85 | PGR (0.63) | GAATSHRLMNAKMT2AMAPT | |
| SCHEMBL22778819 | 0.83 | KDM4E (0.51) | GAATSHRSMN1; SMN2ALDH1A1USP2 | |
| SCHEMBL15853667 | 0.82 | ABCB1 (0.56) | GAATSHRLMNAMEN1KMT2A | |
| SCHEMBL9625113 | 0.79 | JAK2 (0.63) | GAALMNAMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14025545 | 0.79 | ALDH1A1 (0.67) | TSHRLMNASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL22778820 | 0.78 | LMNA (0.55) | TSHRLMNAMEN1KMT2ANPC1 | |
| Methane SCHEMBL10645558 | 0.78 | HRH3 (0.56) | SMN1; SMN2ALDH1A1L3MBTL1HRH3HDAC1 | |
| SCHEMBL2228965 | 0.77 | HRH3 (0.57) | GAAKMT2AMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14025542 | 0.77 | ALDH1A1 (0.68) | LMNASMN1; SMN2ALDH1A1KEAP1L3MBTL1 | |
| SCHEMBL29642975 | 0.77 | HRH3 (0.64) | GAANPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067600-A1 | SMALL MOLECULE INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mtPTP) | UNIVERSITY OF KANSAS (US) | 2024-02-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240067600-A1 | SMALL MOLECULE INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mtPTP) | MTCH2, TIMM50, TIMM10 | GAA 2047/4885TSHR 3992/4885LMNA 842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.