Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182136 | 0.92 | KEAP1 (0.51) | KEAP1NFE2L2MAOAMAOBMEN1 | |
| SCHEMBL181817 | 0.88 | ALDH1A1 (0.49) | KEAP1NFE2L2MAOAMAOBMEN1 | |
| SCHEMBL27824806 | 0.87 | KMO (0.59) | KEAP1NFE2L2MAOAMAOBMEN1 | |
| SCHEMBL182162 | 0.86 | KMO (0.53) | KEAP1NFE2L2KDM4EALDH1A1NPC1 | |
| SCHEMBL2710273 | 0.85 | KMO (0.49) | KEAP1NFE2L2MAOAMAOBMEN1 | |
| SCHEMBL5199932 | 0.85 | MEN1 (0.54) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL181774 | 0.85 | GRM5 (0.47) | KEAP1NFE2L2MAOAMAOBFYN | |
| SCHEMBL182177 | 0.84 | CA2 (0.50) | KEAP1NFE2L2FYNMEN1KMT2A | |
| SCHEMBL2707490 | 0.84 | POLB (0.57) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL2708555 | 0.83 | ALDH1A1 (0.50) | MAOAMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387995-A1 | Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith | PTC Therapeutics, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| WO-2007117438-A2 | METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH | PTC THERAPEUTICS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |