Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 2/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27109564 | 0.72 | KDM4E (0.42) | PDE1BPDE1APDE1CPDE5A | |
| SCHEMBL12844112 | 0.70 | PDE1B (0.55) | PDE1BPDE1APDE1CPDE5A | |
| SCHEMBL11583026 | 0.67 | HTR1A (0.50) | — | |
| SCHEMBL24393048 | 0.66 | PDE1B (0.38) | PDE1BPDE1APDE1CPDE5A | |
| SCHEMBL21863298 | 0.60 | HTT (0.45) | — | |
| SCHEMBL20813807 | 0.59 | PDE5A (0.42) | PDE5A | |
| SCHEMBL21533852 | 0.58 | MEN1 (0.40) | PDE1BPDE5A | |
| SCHEMBL12143431 | 0.58 | PDE5A (0.68) | PDE1BPDE1APDE1CPDE5A | |
| SCHEMBL20350896 | 0.58 | NQO2 (0.46) | PDE5A | |
| SCHEMBL24392596 | 0.58 | PIK3CA (0.43) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327882-A2 | ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER | The Board of Trustees of the Leland Stanford Junior University (US) | 2024-02-28 | — | — | EP | disclosed |