Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.64 |
| ▸ | QDPR | P09417 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 5/20 | 0.50 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2160176 | 0.98 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL1823096 | 0.89 | SLC6A2 (0.81) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL13093036 | 0.89 | SLC6A2 (0.81) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| Hydrochloric Acid SCHEMBL27410631 | 0.87 | SLC6A2 (0.78) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL9870878 | 0.85 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL5585044 | 0.83 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL5584982 | 0.83 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL3384929 | 0.83 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL3383243 | 0.83 | QDPR (0.51) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL31342377 | 0.83 | QDPR (0.51) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104024251-B | Benzenesulfonamide compounds and their use as therapeutic agents | 克赛农制药股份有限公司 | 2017-08-11 | — | — | CN | claimed |
| EP-1963268-B1 | DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NSAB AF NEUROSEARCH SWEDEN AB (DK) | 2010-12-01 | — | — | EP | claimed |
| US-20080269286-A1 | Disubstituted Phenylpiperidines as Modulators of Cortical Catecholaminergic Neurotransmission | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2008-10-30 | — | — | US | claimed |
| EP-1963268-A1 | DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | Neurosearch Sweden AB (SE) | 2008-09-03 | — | — | EP | claimed |
| WO-2007065655-A1 | DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NEUROSEARCH SWEDEN AB (SE) | 2007-06-14 | — | — | WO | claimed |
| US-20240018119-A1 | CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING MENTAL ILLNESS | TRINEURO (KR) | 2024-01-18 | — | — | US | disclosed |
| US-20240018119-A1 | CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING MENTAL ILLNESS | TRINEURO (KR) | 2024-01-18 | — | — | US | disclosed |
| EP-3463357-B1 | (2S)-1-[4-(3,4-DICHLOROPHENYL)PIPERIDIN-L-YL]-3-[2-(5-METHYL-L,3,4-OXADIAZOL-2-YL)BENZO[B]FURAN-4-YLOXY]PROPAN-2-OL OR ITS METABOLITE FOR TREATING ANXIETY DISORDERS | MINERVA NEUROSCIENCES INC (US) | 2023-09-20 | — | — | EP | disclosed |
| CN-110498789-B | Aralkyl piperidine derivative and application thereof in multi-target anti-depression | 上海医药工业研究院 | 2022-04-05 | — | — | CN | disclosed |
| WO-2021241876-A1 | CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING MENTAL ILLNESS | 재단법인 대구경북첨단의료산업진흥재단 | 2021-12-02 | — | — | WO | disclosed |
| CN-108358936-A | Piperazine ketone compounds containing piperidine ring and its preparation method and application | 山东大学 | 2018-08-03 | — | — | CN | disclosed |
| CN-104024251-B | Benzenesulfonamide compounds and their use as therapeutic agents | 克赛农制药股份有限公司 | 2017-08-11 | — | — | CN | disclosed |
| EP-0580398-B1 | Carbamoyl pyrrolidone derivatives for the treatment of depression and cerebrovascular disorders | SHIONOGI & CO (JP) | 1999-11-24 | — | — | EP | disclosed |
| US-5321035-A | Antiserotonin, antiischemic agents | SHIONOGI & CO., LTD. (JP) | 1994-06-14 | — | — | US | disclosed |
| EP-0580398-A1 | Carbamoyl pyrrolidone derivatives for the treatment of depression and cerebnovascular disorders | SHIONOGI & CO., LTD. (JP) | 1994-01-26 | — | — | EP | disclosed |
| EP-0518939-A1 | ANTIARRHYTHMIC AGENTS | BTG INTERNATIONAL LIMITED (GB) | 1992-12-23 | — | — | EP | disclosed |
| WO-1991013865-A1 | ANTIARRHYTHMIC AGENTS | ISIS INNOVATION LIMITED (GB) | 1991-09-19 | — | — | WO | disclosed |
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |
| US-3935227-A | ANTIDEPRESSANTS, ANTIANXIETY, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269286-A1 | Disubstituted Phenylpiperidines as Modulators of Cortical Catecholaminergic Neurotransmission | SLC6A2, SLC18A2, PNMT | SLC6A2 1/4885SLC6A4 15/4885SLC6A3 4/4885 |
| US-20240018119-A1 | CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING MENTAL ILLNESS | MAOA, DRD2, MAOB | SLC6A2 4/4885SLC6A4 23/4885SLC6A3 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.