Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 10/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310741 | 0.92 | ATAD2 (0.58) | ATAD2TDP1CNR2MAPTALDH1A1 | |
| SCHEMBL311084 | 0.92 | TDP1 (0.55) | TDP1CNR2MAPTALDH1A1HSD17B10 | |
| SCHEMBL2015855 | 0.81 | CA1 (0.48) | ATAD2TDP1CNR2MAPTALDH1A1 | |
| SCHEMBL1495498 | 0.81 | TDP1 (0.64) | TDP1CNR2MAPTALDH1A1HSD17B10 | |
| SCHEMBL8410461 | 0.81 | ATAD2 (0.60) | ATAD2TDP1CNR2MAPTALDH1A1 | |
| SCHEMBL2491580 | 0.80 | NPC1 (0.54) | ATAD2TDP1MAPTALDH1A1LMNA | |
| SCHEMBL18172349 | 0.79 | MAPT (0.50) | ATAD2MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL21253164 | 0.79 | ATAD2 (0.50) | ATAD2MAPTALDH1A1HSD17B10HPGD | |
| SCHEMBL18172335 | 0.79 | KDM4E (0.50) | ATAD2MAPTALDH1A1HSD17B10HPGD | |
| SCHEMBL18496642 | 0.79 | SLC6A3 (0.45) | MAPTALDH1A1HPGDKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445889-A1 | NOVEL OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES | F. Hoffmann-La Roche AG (CH) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010149541-A1 | NOVEL OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-29 | — | — | WO | disclosed |