Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27117357 | 0.89 | SOS1 (0.47) | SOS1KMT2ATNKSFFAR4 | |
| SCHEMBL27116892 | 0.89 | SOS1 (0.46) | SOS1KMT2AMEN1ALDH1A1TNKS | |
| SCHEMBL30816879 | 0.88 | SOS1 (0.50) | SOS1MLKLCRBNNR3C1PGR | |
| SCHEMBL30984835 | 0.87 | SOS1 (0.51) | SOS1MLKLCRBNNR3C1PGR | |
| SCHEMBL27117315 | 0.85 | KMT2A (0.44) | SOS1KMT2AALDH1A1TNKS | |
| SCHEMBL31677366 | 0.84 | SOS1 (0.48) | SOS1MLKLCRBNKCNH2KMT2A | |
| SCHEMBL27117280 | 0.84 | PARP1 (0.42) | SOS1CRBNKMT2AALDH1A1TSHR | |
| SCHEMBL30864007 | 0.83 | SOS1 (0.46) | SOS1MLKLCRBNNR3C1PGR | |
| SCHEMBL27116956 | 0.83 | SOS1 (0.42) | SOS1KMT2AMEN1ALDH1A1 | |
| SCHEMBL23134537 | 0.82 | SOS1 (0.45) | SOS1NR3C1PGRSLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4328219-A1 | SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Shanghai Leadingtac Pharmaceutical Co. Ltd. (CN) | 2024-02-28 | — | — | EP | disclosed |