Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713091 | 0.92 | EGFR (0.44) | MAPTKDM4EEGFRKMT2AALDH1A1 | |
| SCHEMBL2713612 | 0.85 | MAPK10 (0.55) | — | |
| SCHEMBL2715553 | 0.84 | SYK (0.49) | EGFRHTTTP53 | |
| SCHEMBL2712356 | 0.83 | JAK3 (0.46) | MAPTKDM4EEGFR | |
| SCHEMBL2692165 | 0.83 | JAK3 (0.64) | MAPTKDM4EEGFRKMT2AALDH1A1 | |
| SCHEMBL2712879 | 0.82 | KDM4E (0.48) | MAPTKDM4EEGFRKMT2AALDH1A1 | |
| SCHEMBL2713076 | 0.81 | JAK3 (0.43) | EGFRPTK2HTT | |
| SCHEMBL2712299 | 0.81 | SYK (0.55) | MAPT | |
| SCHEMBL2714011 | 0.79 | SYK (0.51) | — | |
| SCHEMBL2712825 | 0.79 | JAK3 (0.59) | EGFRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |