Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 4/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714492 | 0.99 | JAK3 (0.43) | JAK3HSD11B1ALDH1A1LCKPARP1 | |
| SCHEMBL3716902 | 0.94 | PARP1 (0.44) | JAK3HSD11B1ALDH1A1LCKPARP1 | |
| SCHEMBL21119052 | 0.86 | ALDH1A1 (0.51) | JAK3HSD11B1ALDH1A1LCKLRRK2 | |
| SCHEMBL2770958 | 0.78 | PARP1 (0.51) | ALDH1A1PARP1HPGDKDM4EHSD17B10 | |
| SCHEMBL15966081 | 0.74 | LRRK2 (0.52) | JAK3LCKLRRK2JAK1JAK2 | |
| SCHEMBL17206946 | 0.74 | LRRK2 (0.46) | JAK3HSD11B1ALDH1A1LCKLRRK2 | |
| SCHEMBL6796063 | 0.72 | PARP1 (0.49) | ALDH1A1PARP1HPGDKDM4EHSD17B10 | |
| SCHEMBL8406937 | 0.72 | MAP2K1 (0.42) | ALDH1A1KCNH2KDM4E | |
| SCHEMBL7456370 | 0.71 | HSD11B1 (0.47) | HSD11B1ALDH1A1PARP1HPGDKDM4E | |
| SCHEMBL3427967 | 0.71 | PARP1 (0.47) | ALDH1A1PARP1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |