Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MELK | Q14680 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713291 | 0.92 | JAK3 (0.45) | SYKIRAK4JAK3JAK2JAK1 | |
| SCHEMBL2713612 | 0.88 | MAPK10 (0.55) | SYKMAPK9MAPK10STAT6 | |
| SCHEMBL2713052 | 0.84 | MAPT (0.48) | HTTEGFRTP53 | |
| SCHEMBL2714011 | 0.82 | SYK (0.51) | SYKJAK2JAK1MAPK9MAPK10 | |
| SCHEMBL2478491 | 0.81 | JAK3 (0.69) | SYKIRAK4JAK3JAK2JAK1 | |
| SCHEMBL2714357 | 0.79 | SYK (0.54) | SYKIRAK4JAK3JAK2JAK1 | |
| SCHEMBL2713091 | 0.79 | EGFR (0.44) | SYKIRAK4JAK3JAK2JAK1 | |
| SCHEMBL2713076 | 0.79 | JAK3 (0.43) | IRAK4JAK3JAK2JAK1TYK2 | |
| SCHEMBL2713978 | 0.79 | SYK (0.54) | SYK | |
| SCHEMBL2712299 | 0.78 | SYK (0.55) | SYKJAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |