Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | WRN | Q14191 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4900667 | 0.83 | GRM4 (0.59) | GRM4NPC1RAB9AAKT1BLM | |
| SCHEMBL13400510 | 0.81 | MEN1 (0.49) | GRM4NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL16088607 | 0.79 | CYP1A2 (0.55) | GRM4NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL2092311 | 0.77 | RAB9A (0.65) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL13022995 | 0.77 | NPC1 (0.46) | GRM4NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL18323173 | 0.77 | NPC1 (0.49) | GRM4NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL15907212 | 0.75 | GRM4 (0.39) | GRM4NPC1RAB9AAKT1KMT2A | |
| SCHEMBL18323190 | 0.75 | ALDH1A1 (0.53) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL28293553 | 0.74 | EGFR (0.41) | GRM4AKT1KMT2AMEN1HTT | |
| SCHEMBL31591018 | 0.73 | LMNA (0.44) | RAB9AKMT2ASMN1; SMN2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052451-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-04-26 | — | — | WO | disclosed |