Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MLNR | O43193 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713076 | 0.92 | JAK3 (0.43) | JAK3LTA4HJAK2JAK1TYK2 | |
| SCHEMBL2713777 | 0.83 | SYK (0.44) | SYKSIRT2JAK3JAK2JAK1 | |
| SCHEMBL2713091 | 0.82 | EGFR (0.44) | SYKKDM4EPOLBJAK3JAK2 | |
| SCHEMBL2713982 | 0.80 | FAAH (0.41) | FAAHKDM4EPOLBGAAMET | |
| SCHEMBL2695958 | 0.78 | JAK3 (0.45) | FAAHSIRT2KDM4EPOLBGAA | |
| SCHEMBL2713291 | 0.78 | JAK3 (0.45) | SYKJAK3JAK2JAK1TYK2 | |
| SCHEMBL2696683 | 0.77 | SIRT2 (0.52) | SIRT2JAK3JAK2JAK1TYK2 | |
| SCHEMBL2695006 | 0.77 | IRAK4 (0.67) | FAAHSYKSIRT2KDM4EPOLB | |
| SCHEMBL2695003 | 0.77 | IRAK4 (0.67) | FAAHSYKSIRT2KDM4EPOLB | |
| SCHEMBL2714011 | 0.77 | SYK (0.51) | SYKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |