Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ULK1 | O75385 | 2/20 | 0.42 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.41 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2715553 | 0.92 | SYK (0.49) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2714011 | 0.86 | SYK (0.51) | JAK2JAK1SYKCCNA2CDK2 | |
| SCHEMBL2713612 | 0.83 | MAPK10 (0.55) | SYK | |
| SCHEMBL2713091 | 0.83 | EGFR (0.44) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2713052 | 0.79 | MAPT (0.48) | — | |
| SCHEMBL2715238 | 0.78 | FAAH (0.42) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2692999 | 0.78 | JAK3 (0.50) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2712360 | 0.77 | SYK (0.45) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2716322 | 0.76 | SYK (0.47) | JAK3SYKCCNA2CDK2 | |
| SCHEMBL2713777 | 0.75 | SYK (0.44) | JAK3IRAK4JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |