Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.44 |
| ▸ | JAK3 | P52333 | 7/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2712356 | 0.91 | JAK3 (0.46) | SYKJAK3IRAK4JAK2JAK1 | |
| SCHEMBL2713091 | 0.84 | EGFR (0.44) | SYKJAK3IRAK4JAK2JAK1 | |
| SCHEMBL2715238 | 0.83 | FAAH (0.42) | SYKJAK3IRAK4JAK2JAK1 | |
| SCHEMBL2695863 | 0.78 | JAK3 (0.48) | SYKJAK3IRAK4JAK2JAK1 | |
| SCHEMBL2716322 | 0.76 | SYK (0.47) | SYKJAK3 | |
| SCHEMBL2713052 | 0.76 | MAPT (0.48) | — | |
| SCHEMBL2712360 | 0.75 | SYK (0.45) | SYKJAK3IRAK4JAK2JAK1 | |
| SCHEMBL2714011 | 0.75 | SYK (0.51) | SYKJAK2JAK1 | |
| SCHEMBL2713291 | 0.75 | JAK3 (0.45) | SYKJAK3IRAK4JAK2JAK1 | |
| SCHEMBL2713076 | 0.74 | JAK3 (0.43) | JAK3IRAK4JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |