Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713052 | 0.92 | MAPT (0.48) | EGFRMAPTKDM4EKMT2AMEN1 | |
| SCHEMBL2714048 | 0.84 | EGFR (0.45) | EGFRITKFKBP1AROCK2MAPT | |
| SCHEMBL2713777 | 0.84 | SYK (0.44) | PDE4BJAK2JAK1TYK2JAK3 | |
| SCHEMBL2694016 | 0.83 | JAK3 (0.62) | EGFRITKFKBP1AROCK2MAPT | |
| SCHEMBL2714011 | 0.83 | SYK (0.51) | JAK2JAK1SYK | |
| SCHEMBL2713291 | 0.83 | JAK3 (0.45) | JAK2JAK1TYK2JAK3IRAK4 | |
| SCHEMBL2715238 | 0.82 | FAAH (0.42) | KDM4EJAK2JAK1TYK2JAK3 | |
| SCHEMBL2713612 | 0.80 | MAPK10 (0.55) | SYK | |
| SCHEMBL2715553 | 0.79 | SYK (0.49) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL2695869 | 0.79 | JAK3 (0.45) | EGFRITKFKBP1AROCK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |