Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 17/20 | 0.78 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15346636 | 0.95 | PDPK1 (0.70) | PDPK1PTGS2 | |
| SCHEMBL15346826 | 0.92 | PDPK1 (0.77) | PDPK1PTGS2 | |
| SCHEMBL2732571 | 0.91 | PDPK1 (0.72) | PDPK1PTGS2 | |
| SCHEMBL15347121 | 0.90 | PTGS2 (0.72) | PDPK1PTGS2 | |
| SCHEMBL19665014 | 0.89 | PDPK1 (0.61) | PDPK1PTGS2CA9 | |
| SCHEMBL15347005 | 0.88 | PDPK1 (0.64) | PDPK1PTGS2 | |
| SCHEMBL29464040 | 0.88 | PDPK1 (1.00) | PDPK1PTGS2CA9 | |
| SCHEMBL5672824 | 0.88 | PDPK1 (1.00) | PDPK1PTGS2CA9 | |
| SCHEMBL15346851 | 0.86 | PDPK1 (0.77) | PDPK1PTGS2 | |
| SCHEMBL15346527 | 0.85 | PTGS2 (0.74) | PDPK1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019156946-A2 | COMPOSITIONS AND METHODS FOR IMPROVING CFTR FUNCTION IN CYSTIC FIBROSIS-AFFECTED CELLS | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2019-08-15 | — | — | WO | disclosed |
| EP-3363435-A1 | ANTI-STAPHYLOCOCCAL CELECOXIB DERIVATIVES | The Ohio State University Research Foundation (US) | 2018-08-22 | — | — | EP | disclosed |
| US-10028933-B2 | Compositions and methods for inhibiting the growth of multi-drug resistant microbes | OHIO STATE INNOVATION FOUNDATION (US) | 2018-07-24 | — | — | US | disclosed |
| US-10028933-B2 | Compositions and methods for inhibiting the growth of multi-drug resistant microbes | OHIO STATE INNOVATION FOUNDATION (US) | 2018-07-24 | — | — | US | disclosed |
| WO-2018089374-A1 | COMPOSITIONS AND METHODS FOR INHIBITING THE GROWTH OF FRANCISELLA | OHIO STATE INNOVATION FOUNDATION (US) | 2018-05-17 | — | — | WO | disclosed |
| EP-2635274-B1 | ANTI-STAPHYLOCOCCAL CELECOXIB DERIVATIVES | UNIV OHIO STATE RES FOUND (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-2635274-B1 | ANTI-STAPHYLOCOCCAL CELECOXIB DERIVATIVES | UNIV OHIO STATE RES FOUND (US) | 2017-12-06 | — | — | EP | disclosed |
| US-20170020846-A1 | COMPOSITIONS AND METHODS FOR INHIBITING THE GROWTH OF MULTI-DRUG RESISTANT MICROBES | OHIO STATE INNOVATION FOUNDATION | 2017-01-26 | — | — | US | disclosed |
| US-20170020846-A1 | COMPOSITIONS AND METHODS FOR INHIBITING THE GROWTH OF MULTI-DRUG RESISTANT MICROBES | OHIO STATE INNOVATION FOUNDATION | 2017-01-26 | — | — | US | disclosed |
| WO-2017015352-A1 | COMPOSITIONS AND METHODS FOR INHIBITING THE GROWTH OF MULTI-DRUG RESISTANT MICROBES | OHIO STATE INNOVATION FOUNDATION (US) | 2017-01-26 | — | — | WO | disclosed |
| US-9457031-B2 | Antibacterial protein kinase inhibitors | OHIO STATE INNOVATION FOUNDATION | 2016-10-04 | — | — | US | disclosed |
| US-20150258100-A1 | ANTIBACTERIAL PROTEIN KINASE INHIBITORS | OHIO STATE INNOVATION FOUNDATION | 2015-09-17 | — | — | US | disclosed |
| US-20150258100-A1 | ANTIBACTERIAL PROTEIN KINASE INHIBITORS | OHIO STATE INNOVATION FOUNDATION | 2015-09-17 | — | — | US | disclosed |
| US-9079899-B2 | Anti-staphylococcal celecoxib derivatives | THE OHIO STATE UNIVERSITY (US) | 2015-07-14 | — | — | US | disclosed |
| US-9079899-B2 | Anti-staphylococcal celecoxib derivatives | THE OHIO STATE UNIVERSITY (US) | 2015-07-14 | — | — | US | disclosed |
| US-20130289004-A1 | ANTI-STAPHYLOCOCCAL CELECOXIB DERIVATIVES | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-10-31 | — | — | US | disclosed |
| US-20130289004-A1 | ANTI-STAPHYLOCOCCAL CELECOXIB DERIVATIVES | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-10-31 | — | — | US | disclosed |
| EP-2635274-A1 | ANTI-STAPHYLOCOCCAL CELECOXIB DERIVATIVES | The Ohio State University Research Foundation (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061260-A1 | ANTI-STAPHYLOCOCCAL CELECOXIB DERIVATIVES | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012061260-A1 | ANTI-STAPHYLOCOCCAL CELECOXIB DERIVATIVES | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130289004-A1 | ANTI-STAPHYLOCOCCAL CELECOXIB DERIVATIVES | PTGS1, IL17A, IKBKE | PDPK1 2310/4885PTGS2 13/4885CA9 776/4885 |
| US-10028933-B2 | Compositions and methods for inhibiting the growth of multi-drug resistant microbes | MMP13, MICOS13, AR | PDPK1 3584/4885PTGS2 2307/4885CA9 707/4885 |
| US-20150258100-A1 | ANTIBACTERIAL PROTEIN KINASE INHIBITORS | DMPK, MYLK3, MYLK2 | PDPK1 110/4885PTGS2 340/4885CA9 3875/4885 |
| US-20170020846-A1 | COMPOSITIONS AND METHODS FOR INHIBITING THE GROWTH OF MULTI-DRUG RESISTANT MICROBES | MMP13, MICOS13, AR | PDPK1 3584/4885PTGS2 2307/4885CA9 707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.