Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 5/20 | 0.35 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.31 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30853390 | 0.89 | EGFR (0.37) | ECE1EGFRFGFR1KDRMETAP2 | |
| SCHEMBL27187216 | 0.89 | EGFR (0.39) | ECE1EGFRFGFR1KDRMETAP2 | |
| SCHEMBL27186991 | 0.75 | HSD17B10 (0.50) | HSD17B10KDM4E | |
| SCHEMBL27186383 | 0.71 | BRD4 (0.38) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL27186394 | 0.70 | ALDH1A1 (0.36) | PRKAG1PRKAA1PRKAB1HSP90AA1GAA | |
| SCHEMBL27186283 | 0.67 | PRKAB2 (0.35) | PRKAG1PRKAA1PRKAB1HSD17B10PRKAB2 | |
| SCHEMBL29168454 | 0.65 | PKM (0.31) | KDM4E | |
| SCHEMBL29168406 | 0.65 | CDC25B (0.48) | GAAHSD17B10KDM4ECLK1 | |
| SCHEMBL27186349 | 0.63 | NR4A2 (0.40) | HSD17B10KDM4E | |
| SCHEMBL27186983 | 0.63 | KDM4E (0.38) | HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109887-A1 | NOVEL SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AS SOS1 INHIBITORS | VIVA STAR BIOSCIENCES (SUZHOU) CO., LTD. (CN) | 2024-04-04 | — | — | US | disclosed |
| CN-117651701-A | Novel substituted bicyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-03-05 | — | — | CN | disclosed |
| WO-2022187266-A1 | NOVEL SUBSTITUTED BICYCLI AZA-HETEROCYCLES AS SOS1 INHIBITORS | VIVA STAR BIOSCIENCES (SUZHOU) CO., LTD. (CN) | 2022-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109887-A1 | NOVEL SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AS SOS1 INHIBITORS | SOS1, SOS2, KSR1 | ECE1 2029/4885EGFR 1060/4885FGFR1 1726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.