SCHEMBL27196460

SCHEMBL27196460

ON=Cc1cc(-c2ncccc2Cl)c(F)cc1Cl

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ NPC1 O15118 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ ALDH1A1 P00352 2/20 0.35
▸ HPGD P15428 2/20 0.35
▸ USP2 O75604 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ FGF23 Q9GZV9 1/20 0.34
▸ NTRK1 P04629 2/20 0.33
▸ RORC P51449 3/20 0.32
▸ GPBAR1 Q8TDU6 1/20 0.32
▸ KCNN4 O15554 2/20 0.32
▸ DPP4 P27487 1/20 0.32
▸ TSHR P16473 1/20 0.32
▸ HCRTR1 O43613 1/20 0.31
▸ HCRTR2 O43614 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ CTSA P10619 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27196550 0.82 ERN1 (0.37) NTRK1RORCGPBAR1DPP4
SCHEMBL27196519 0.80 HTR5A (0.38) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL29055093 0.80 HTR5A (0.39) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL24485240 0.75 ALDH1A1 (0.43) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL29055160 0.75 ALDH1A1 (0.43) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL29712898 0.73 DPP4 (0.40) MAPTSMN1; SMN2ALDH1A1LMNANTRK1
SCHEMBL27196544 0.73 SLC2A1 (0.41) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL30525128 0.72 NPC1 (0.32) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL27196495 0.72 NPC1 (0.32) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL31438594 0.72 CCR1 (0.41) MAPTSMN1; SMN2NPC1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240124432-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2024-04-18 — — US disclosed
EP-4250928-A1 HERBICIDAL COMPOUNDS Syngenta Crop Protection AG (CH) 2023-10-04 — — EP disclosed
CN-116568673-A Herbicidal compounds 先正达农作物保护股份公司 2023-08-08 — — CN disclosed
WO-2022112072-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-06-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124432-A1 HERBICIDAL COMPOUNDS DDT, ACHE, GSTO1 MAPT 4021/4885SMN1; SMN2 2706/4885NPC1 3704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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