Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29690274 | 0.85 | MMP3 (0.51) | MMP3TGFBR1BACE1 | |
| SCHEMBL28810411 | 0.85 | MMP3 (0.51) | MMP3TGFBR1BACE1 | |
| SCHEMBL2720290 | 0.84 | PRKCI (0.51) | TGFBR1BACE1ROCK2ADORA3ADORA2A | |
| SCHEMBL2721306 | 0.84 | ROCK2 (0.41) | BACE1ROCK2PRMT6EPHX2ADORA3 | |
| SCHEMBL2721710 | 0.82 | AURKA (0.41) | BACE1ROCK2ADORA3ADORA2A | |
| SCHEMBL2719181 | 0.82 | MAP4K4 (0.44) | BACE1ROCK2PRMT6EPHX2ADORA3 | |
| SCHEMBL2719580 | 0.82 | NEK1 (0.43) | TGFBR1BACE1ROCK2CYP11B2 | |
| SCHEMBL2721585 | 0.80 | ROCK2 (0.44) | ROCK2ADORA3ADORA2ACYP11B2TOP2A | |
| SCHEMBL2718534 | 0.79 | AOC3 (0.52) | TNIK | |
| SCHEMBL2721311 | 0.79 | DRD2 (0.49) | GSK3BCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635575-A1 | CARBAZOLE AND CARBOLINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC APPLICATIONS THEREOF | Philip Morris Products S.a.s. (CH) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012059232-A1 | CARBAZOLE AND CARBOLINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC APPLICATIONS THEREOF | PHILIP MORRIS PRODUCTS S.A (CH) | 2012-05-10 | — | — | WO | disclosed |