Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | BCKDK | O14874 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2719376 | 0.90 | MGLL (0.47) | ALDH1A1LMNARECQLRAB9AKDM4E | |
| SCHEMBL2721078 | 0.81 | MGLL (0.37) | MGLLCYP3A4 | |
| SCHEMBL10175385 | 0.80 | ALDH1A1 (0.52) | ALDH1A1LMNARECQLRAB9AKDM4E | |
| SCHEMBL912949 | 0.75 | MGLL (0.55) | ALDH1A1LMNARECQLRAB9AKDM4E | |
| SCHEMBL2721140 | 0.73 | SLC6A7 (0.45) | ALDH1A1SMN1; SMN2TSHRMGLL | |
| SCHEMBL2721328 | 0.70 | SLC6A7 (0.46) | MGLL | |
| SCHEMBL14877190 | 0.70 | MGLL (0.55) | ALDH1A1LMNARECQLRAB9AKDM4E | |
| SCHEMBL10175834 | 0.70 | MGLL (0.55) | ALDH1A1LMNARECQLRAB9AKDM4E | |
| SCHEMBL2130880 | 0.68 | CYP3A4 (0.43) | ALDH1A1LMNARECQLRAB9AKDM4E | |
| SCHEMBL14877268 | 0.67 | MGLL (0.62) | ALDH1A1LMNARECQLRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2629851-A1 | PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2013-08-28 | — | — | EP | disclosed |
| WO-2012054716-A1 | PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV. (BE) | 2012-04-26 | — | — | WO | disclosed |