Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 5/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2721328 | 0.89 | SLC6A7 (0.46) | SLC6A7MGLL | |
| SCHEMBL2718845 | 0.80 | GPR52 (0.41) | SLC6A7ALDH1A1SMN1; SMN2 | |
| SCHEMBL10175842 | 0.76 | SLC6A7 (0.57) | SLC6A7HTR2BMGLLALDH1A1TSHR | |
| SCHEMBL2719941 | 0.73 | ALDH1A1 (0.42) | MGLLALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL2729620 | 0.72 | CHRNB2 (0.59) | SLC6A7CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL2721078 | 0.72 | MGLL (0.37) | CHRNA4MGLL | |
| SCHEMBL2131175 | 0.72 | CYP3A4 (0.55) | SLC6A7HTR2BMGLLALDH1A1TSHR | |
| SCHEMBL15253868 | 0.70 | SLC6A7 (0.39) | SLC6A7CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL911408 | 0.70 | MGLL (0.69) | SLC6A7MGLLALDH1A1TSHRMAPK1 | |
| SCHEMBL911279 | 0.70 | MGLL (0.69) | SLC6A7MGLLALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2629851-A1 | PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2013-08-28 | — | — | EP | disclosed |
| WO-2012054716-A1 | PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV. (BE) | 2012-04-26 | — | — | WO | disclosed |