Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | BDKRB1 | P46663 | 8/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1994212 | 0.89 | CA12 (0.55) | CA12CA1CA2CA7CA9 | |
| SCHEMBL13208390 | 0.86 | CA2 (0.48) | CA12CA1CA2CA7CA9 | |
| SCHEMBL26657525 | 0.86 | CES2 (0.47) | CES2CES1RORCITGB1ITGA4 | |
| SCHEMBL22400331 | 0.83 | LMNA (0.43) | CES2CES1RORCKMT2ASTIM1 | |
| SCHEMBL1070351 | 0.83 | CA12 (0.61) | CA12CA1CA2CA7CA9 | |
| SCHEMBL24445845 | 0.83 | CA12 (0.69) | CA12CA1CA2CA7CA9 | |
| SCHEMBL8570598 | 0.83 | CFTR (0.49) | CA12CA1CA2CA7CA9 | |
| SCHEMBL15568652 | 0.81 | TYK2 (0.54) | CA12CA1CA2CA7CA9 | |
| SCHEMBL7932574 | 0.81 | NOTUM (0.49) | CA12CA1CA2CA7CA9 | |
| SCHEMBL30313345 | 0.80 | CES2 (0.48) | NOTUMCES2CES1RORCKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108341801-A | Polyfluoro substitution virtue connection heterocyclic derivative, the pharmaceutical composition containing it and its application | 浙江大学 | 2018-07-31 | — | — | CN | disclosed |
| US-9156791-B2 | Pyrazole compounds acting against allergic, immune and inflammatory conditions | GLAXO GROUP LIMITED (GB) | 2015-10-13 | — | — | US | disclosed |
| US-9156791-B2 | Pyrazole compounds acting against allergic, immune and inflammatory conditions | GLAXO GROUP LIMITED (GB) | 2015-10-13 | — | — | US | disclosed |
| US-9149462-B2 | Pyrazole compounds acting against allergic, inflammatory and immune disorders | GLAXO GROUP LIMITED (GB) | 2015-10-06 | — | — | US | disclosed |
| US-9149462-B2 | Pyrazole compounds acting against allergic, inflammatory and immune disorders | GLAXO GROUP LIMITED (GB) | 2015-10-06 | — | — | US | disclosed |
| US-9149462-B2 | Pyrazole compounds acting against allergic, inflammatory and immune disorders | GLAXO GROUP LIMITED (GB) | 2015-10-06 | — | — | US | disclosed |
| EP-2630126-B1 | PYRAZOLE COMPOUNDS ACTING AGAINST ALLERGIC, IMMUNE AND INFLAMMATORY CONDITIONS | GLAXO GROUP LTD (GB) | 2015-01-07 | — | — | EP | disclosed |
| EP-2630126-B1 | PYRAZOLE COMPOUNDS ACTING AGAINST ALLERGIC, IMMUNE AND INFLAMMATORY CONDITIONS | GLAXO GROUP LTD (GB) | 2015-01-07 | — | — | EP | disclosed |
| EP-2630127-A1 | PYRAZOLE COMPOUNDS ACTING AGAINST ALLERGIC, INFLAMMATORY AND IMMUNE DISORDERS | Glaxo Group Limited (GB) | 2013-08-28 | — | — | EP | disclosed |
| EP-2630126-A1 | PYRAZOLE COMPOUNDS ACTING AGAINST ALLERGIC, IMMUNE AND INFLAMMATORY CONDITIONS | Glaxo Group Limited (GB) | 2013-08-28 | — | — | EP | disclosed |
| WO-2012052459-A1 | PYRAZOLE COMPOUNDS ACTING AGAINST ALLERGIC, INFLAMMATORY AND IMMUNE DISORDERS | GLAXO GROUP LIMITED (GB) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012052459-A1 | PYRAZOLE COMPOUNDS ACTING AGAINST ALLERGIC, INFLAMMATORY AND IMMUNE DISORDERS | GLAXO GROUP LIMITED (GB) | 2012-04-26 | — | — | WO | disclosed |
| CN-1057524-C | Herbicides | RHONE POULENC AGROCH (GB) | 2000-10-18 | — | — | CN | disclosed |
| US-5859283-A | TERTIARY-BUTYL 3-CYCLOALKYL-3-OXOPROPIONATE | RHONE-POULENC AGRICULTURE LIMITED (GB) | 1999-01-12 | — | — | US | disclosed |
| US-5747424-A | HEATING AN AROMATIC DIKETONE WITH A SALT OF HYDROXYLAMINE IN A SOLVENT | RHONE-POULENC AGRICULTURE LTD. (GB) | 1998-05-05 | — | — | US | disclosed |
| US-5656573-A | Herbicidal 4-substituted isoxazoles | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-08-12 | — | — | US | disclosed |
| EP-0560482-B1 | 4-Benzoyl isoxazole derivatives and their use as herbicides | RHONE POULENC AGRICULTURE (GB) | 1997-08-06 | — | — | EP | disclosed |
| US-5650533-A | Intermediates to herbicidal 4-substituted isoxazoles | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-07-22 | — | — | US | disclosed |
| EP-0560482-A1 | 4-Benzoyl isoxazoles derivatives and their use as herbicides | RHONE-POULENC AGRICULTURE LTD. (GB) | 1993-09-15 | — | — | EP | disclosed |
| CN-1076194-A | Weedicide | RHONE POULENC AGRICULTURE (GB) | 1993-09-15 | — | — | CN | disclosed |