SCHEMBL22400331

SCHEMBL22400331

CC(C)(C)OC(=O)c1c(F)cccc1C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.43
POLB P06746 1/20 0.43
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
NR1H2 P55055 3/20 0.39
NR1H3 Q13133 3/20 0.39
RXRA P19793 1/20 0.39
KMT2A Q03164 2/20 0.38
RORC P51449 3/20 0.38
RORB Q92753 1/20 0.37
GRM6 O15303 1/20 0.37
STIM1 Q13586 1/20 0.36
ORAI1 Q96D31 1/20 0.36
AR P10275 1/20 0.36
KAT6A Q92794 1/20 0.36
CNR2 P34972 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2720902 0.83 CA12 (0.48) CES2CES1KMT2ARORCSTIM1
SCHEMBL26657525 0.83 CES2 (0.47) LMNACES2CES1KMT2ARORC
SCHEMBL18131333 0.80 CES2 (0.44) LMNACES2CES1KMT2AGRM6
SCHEMBL6356349 0.80 KMT2A (0.46) LMNAPOLBCES2CES1KMT2A
SCHEMBL17374999 0.80 CA12 (0.48) LMNAPOLBCES2CES1KMT2A
SCHEMBL3849570 0.79 CES2 (0.42) LMNACES2CES1KMT2AGRM6
SCHEMBL10982569 0.79 GRM6 (0.43) LMNACES2CES1KMT2AGRM6
SCHEMBL22207748 0.78 NOTUM (0.40) LMNAPOLBCES2NR1H2NR1H3
SCHEMBL30313345 0.78 CES2 (0.48) CES2CES1KMT2ARORCRORB
SCHEMBL716995 0.78 CES2 (0.48) CES2CES1KMT2ARORCRORB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250122226-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES NOVO NORDISK AS (DK) 2025-04-17 US disclosed
US-12227528-B2 Glucose-sensitive albumin-binding derivatives NOVO NORDISK A/S (DK) 2025-02-18 US disclosed
CN-117624207-A Glucose-sensitive albumin binding derivatives 诺和诺德股份有限公司 2024-03-01 CN disclosed
CN-111315751-B Glucose-sensitive albumin binding derivatives 诺和诺德股份有限公司 2023-12-12 CN disclosed
US-20230331745-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES NOVO NORDISK AS (DK) 2023-10-19 US disclosed
US-20230331745-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES NOVO NORDISK AS (DK) 2023-10-19 US disclosed
US-11767332-B2 Glucose-sensitive albumin-binding derivatives NOVO NORDISK A/S (DK) 2023-09-26 US disclosed
US-11767332-B2 Glucose-sensitive albumin-binding derivatives NOVO NORDISK A/S (DK) 2023-09-26 US disclosed
EP-4227313-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES Novo Nordisk A/S (DK) 2023-08-16 EP disclosed
EP-3707145-B1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES NOVO NORDISK AS (DK) 2023-06-21 EP disclosed
US-20220081451-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES NOVO NORDISK AS (DK) 2022-03-17 US disclosed
US-11186595-B2 Glucose-sensitive albumin-binding derivatives NOVO NORDISK A/S (DK) 2021-11-30 US disclosed
US-20200325160-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES NOVO NORDISK A/S (DK) 2020-10-15 US disclosed
EP-3707145-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES Novo Nordisk A/S (DK) 2020-09-16 EP disclosed
CN-111315751-A Glucose-sensitive albumin binding derivatives 诺沃挪第克公司 2020-06-19 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12227528-B2 Glucose-sensitive albumin-binding derivatives ALB, DBI, FABP4 LMNA 4627/4885POLB 4790/4885CES2 991/4885
US-20230331745-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES ALB, DBI, FABP4 LMNA 4627/4885POLB 4790/4885CES2 991/4885
US-11767332-B2 Glucose-sensitive albumin-binding derivatives ALB, DBI, FABP4 LMNA 4627/4885POLB 4790/4885CES2 991/4885
US-20220081451-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES ALB, DBI, FABP4 LMNA 4627/4885POLB 4790/4885CES2 991/4885
US-20250122226-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES ALB, DBI, FABP4 LMNA 4627/4885POLB 4790/4885CES2 991/4885
US-11186595-B2 Glucose-sensitive albumin-binding derivatives ALB, GPR119, MLX LMNA 4214/4885POLB 4591/4885CES2 816/4885
US-20200325160-A1 GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES ALB, GPR119, MLX LMNA 4214/4885POLB 4591/4885CES2 816/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.