Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL784838 | 0.78 | CA1 (0.44) | KMT2ACA1CA2MAPK1CA9 | |
| SCHEMBL27211973 | 0.75 | LTA4H (0.40) | POLBHTR6HRH3DRD2LTA4H | |
| Hydrochloric Acid SCHEMBL4740172 | 0.73 | HTR6 (0.53) | POLBKMT2AHTR6 | |
| SCHEMBL10153575 | 0.72 | CHRNB2 (0.56) | POLBCHRNB2CHRNA4HTR6CHRNB4 | |
| SCHEMBL5347275 | 0.71 | POLB (0.50) | POLBCHRNB2CHRNA4HTR6CHRNB4 | |
| SCHEMBL2852456 | 0.69 | CA1 (0.53) | KMT2ACA1CA2MAPK1CA9 | |
| SCHEMBL2109274 | 0.69 | POLB (0.58) | POLBCHRNB2CHRNA4HTR6HRH3 | |
| SCHEMBL25281271 | 0.68 | POLB (0.57) | POLBCHRNB2CHRNA4HRH3LTA4H | |
| SCHEMBL3448835 | 0.68 | CA2 (0.51) | KMT2ACA1CA2MAPK1CA9 | |
| SCHEMBL27801396 | 0.67 | CA2 (0.47) | KMT2ACA1CA2MAPK1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4364804-A2 | INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | Janssen Pharmaceutica NV (BE) | 2024-05-08 | — | — | EP | disclosed |