SCHEMBL27218643

SCHEMBL27218643

COc1ccc(-c2cnc(CSc3nc(O)cc(C(F)F)n3)o2)cc1Cl

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
LMNA P02545 5/20 0.35
MAPT P10636 5/20 0.35
HTT P42858 2/20 0.35
TSHR P16473 1/20 0.35
MAPK1 P28482 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
CACNA1G O43497 1/20 0.35
CACNA1B Q00975 1/20 0.35
ALDH1A1 P00352 3/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
HPGD P15428 2/20 0.34
USP2 O75604 1/20 0.34
GRM2 Q14416 1/20 0.34
PTPN1 P18031 2/20 0.33
PTGS2 P35354 2/20 0.33
PTGS1 P23219 1/20 0.33
TDP1 Q9NUW8 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27218802 0.87 ALDH1A1 (0.42) MEN1KMT2ALMNAMAPTHTT
SCHEMBL27218760 0.86 MAPK1 (0.48) MEN1KMT2ALMNAMAPTHTT
SCHEMBL27218658 0.85 MAPT (0.42) MEN1KMT2ALMNAMAPTTSHR
SCHEMBL27218740 0.83 VCP (0.42) MEN1KMT2ALMNAMAPTHTT
SCHEMBL27218854 0.83 LMNA (0.40) MEN1KMT2ALMNAMAPTHTT
SCHEMBL27218880 0.83 SMN1; SMN2 (0.42) MEN1KMT2ALMNAMAPTHTT
SCHEMBL27218774 0.82 FFAR1 (0.40) MEN1KMT2ALMNAMAPTHTT
SCHEMBL27218946 0.79 HPGD (0.35) MEN1KMT2AMAPTTSHRALDH1A1
SCHEMBL27218878 0.79 SMN1; SMN2 (0.43) MEN1KMT2ALMNAMAPTHTT
SCHEMBL31494398 0.77 ADORA2A (0.40) MEN1KMT2ALMNAMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4232448-B1 AGONISTS OF FREE FATTY ACID RECEPTOR 1 AND THEIR USE IN DISEASES ASSOCIATED WITH SAID RECEPTOR Halo Therapeutics Ltd (GB) 2025-05-07 EP disclosed
EP-3956323-B1 OXAZOLE AND OXADIAZOLE DERIVATIVES USEFUL AS AGONISTS OF FREE FATTY ACID RECEPTOR 1 Halo Therapeutics Ltd (GB) 2025-03-05 EP disclosed
US-20240158382-A1 Agonists Of Free Fatty Acid Receptor 1 And Their Use In Diseases Associated With Said Receptor Halo Therapeutics Ltd (GB) 2024-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240158382-A1 Agonists Of Free Fatty Acid Receptor 1 And Their Use In Diseases Associated With Said Receptor FFAR1, FFAR2, FFAR3 MEN1 4478/4885KMT2A 3043/4885LMNA 3526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.