SCHEMBL27218807

SCHEMBL27218807

COc1ccc(-c2nc(CSc3nc(C)cc(N)n3)cs2)cc1

nearest known ligand 0.87

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 2/20 0.61
▸ NPC1 O15118 1/20 0.61
▸ LMNA P02545 1/20 0.61
▸ MAPT P10636 1/20 0.61
▸ HPGD P15428 1/20 0.61
▸ SMN1; SMN2 Q16637 1/20 0.61
▸ DCK P27707 8/20 0.57
▸ ADORA1 P30542 4/20 0.54
▸ ALDH1A1 P00352 2/20 0.52
▸ ATM Q13315 1/20 0.52
▸ KDM4E B2RXH2 1/20 0.51
▸ TDP1 Q9NUW8 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12694440 0.93 DCK (0.64) RAB9ADCKADORA1ALDH1A1KDM4E
SCHEMBL19032933 0.82 DCK (0.63) RAB9ANPC1LMNAMAPTHPGD
SCHEMBL19032952 0.81 RAB9A (0.58) RAB9ANPC1LMNAMAPTHPGD
SCHEMBL19032927 0.81 DCK (0.61) RAB9ANPC1LMNAMAPTHPGD
SCHEMBL27218721 0.78 RAB9A (0.44) RAB9ANPC1LMNAMAPTHPGD
SCHEMBL27218704 0.76 PTGS2 (0.48) RAB9ANPC1LMNAMAPTHPGD
SCHEMBL12694443 0.75 DCK (0.80) MAPTSMN1; SMN2DCKALDH1A1KDM4E
SCHEMBL27218684 0.74 NPSR1 (0.51) RAB9ANPC1LMNAMAPTHPGD
SCHEMBL19032928 0.73 DCK (0.86) MAPTSMN1; SMN2DCKALDH1A1KDM4E
SCHEMBL27218874 0.73 HTT (0.69) RAB9ANPC1LMNAMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4232448-B1 AGONISTS OF FREE FATTY ACID RECEPTOR 1 AND THEIR USE IN DISEASES ASSOCIATED WITH SAID RECEPTOR Halo Therapeutics Ltd (GB) 2025-05-07 — — EP disclosed
EP-3956323-B1 OXAZOLE AND OXADIAZOLE DERIVATIVES USEFUL AS AGONISTS OF FREE FATTY ACID RECEPTOR 1 Halo Therapeutics Ltd (GB) 2025-03-05 — — EP disclosed
US-20240158382-A1 Agonists Of Free Fatty Acid Receptor 1 And Their Use In Diseases Associated With Said Receptor Halo Therapeutics Ltd (GB) 2024-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240158382-A1 Agonists Of Free Fatty Acid Receptor 1 And Their Use In Diseases Associated With Said Receptor FFAR1, FFAR2, FFAR3 RAB9A 2474/4885NPC1 781/4885LMNA 3526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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