Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | HPGD | P15428 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7915531 | 0.98 | ALDH1A1 (0.66) | ALDH1A1HPGDKDM4EHTTSMN1; SMN2 | |
| SCHEMBL16892342 | 0.81 | KDM4E (0.48) | ALDH1A1HPGDKDM4EHTTSMN1; SMN2 | |
| SCHEMBL4429156 | 0.78 | KDM4E (0.44) | ALDH1A1HPGDKDM4EHTTSMN1; SMN2 | |
| SCHEMBL15045557 | 0.78 | CYP2A6 (0.45) | ALDH1A1HPGDKDM4EHTTSMN1; SMN2 | |
| SCHEMBL15045566 | 0.77 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4EHTTSMN1; SMN2 | |
| SCHEMBL13561660 | 0.76 | CYP1A2 (0.46) | ALDH1A1HPGDKDM4EHTTSMN1; SMN2 | |
| SCHEMBL28669933 | 0.75 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4EHTTSMN1; SMN2 | |
| SCHEMBL4916031 | 0.73 | ALDH1A1 (0.58) | ALDH1A1HPGDKDM4EHTTSMN1; SMN2 | |
| SCHEMBL30494604 | 0.73 | ALDH1A1 (0.53) | ALDH1A1HPGDKDM4EHTTSMN1; SMN2 | |
| SCHEMBL15045445 | 0.73 | KEAP1 (0.47) | ALDH1A1HPGDKDM4EHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240158639-A1 | PROCESS FOR PREPARING INDOCYANINE GREEN | ICROM SRL (IT) | 2024-05-16 | — | — | US | disclosed |
| EP-4314167-A1 | PROCESS FOR PREPARING INDOCYANINE GREEN | Icrom Srl (IT) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022200991-A1 | PROCESS FOR PREPARING INDOCYANINE GREEN | ICROM SRL (IT) | 2022-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240158639-A1 | PROCESS FOR PREPARING INDOCYANINE GREEN | INTS9, CA9, SCN9A | ALDH1A1 385/4885HPGD 685/4885KDM4E 2681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.