SCHEMBL27220171

SCHEMBL27220171

COc1cccc(/C=C/C(=O)Oc2ccc(C=O)cc2)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.67
▸ MEN1 O00255 2/20 0.67
▸ KDM4E B2RXH2 1/20 0.67
▸ GAA P10253 1/20 0.67
▸ MAOB P27338 3/20 0.60
▸ FOS P01100 1/20 0.57
▸ JUN P05412 1/20 0.57
▸ BCHE P06276 1/20 0.57
▸ ABCG2 Q9UNQ0 2/20 0.56
▸ RELA Q04206 2/20 0.56
▸ MAPT P10636 2/20 0.55
▸ MAOA P21397 2/20 0.53
▸ CYP1A1 P04798 2/20 0.53
▸ CYP1A2 P05177 2/20 0.53
▸ CYP2D6 P10635 2/20 0.53
▸ CYP1B1 Q16678 2/20 0.53
▸ HTR1A P08908 1/20 0.52
▸ NR1H4 Q96RI1 2/20 0.52
▸ NPC1 O15118 1/20 0.52
▸ LMNA P02545 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27220187 0.86 NQO2 (0.60) KMT2AMEN1KDM4EGAAMAOB
SCHEMBL27220371 0.85 KMT2A (0.63) KMT2AMEN1KDM4EGAAMAOB
SCHEMBL27220203 0.85 KMT2A (0.63) KMT2AMEN1KDM4EGAAMAOB
SCHEMBL27220249 0.85 KMT2A (0.73) KMT2AMEN1MAOBBCHERELA
SCHEMBL3290630 0.82 MAOB (0.66) KMT2AMEN1KDM4EGAAMAOB
SCHEMBL3290633 0.82 MAOB (0.66) KMT2AMEN1KDM4EGAAMAOB
SCHEMBL31737429 0.82 MAOB (0.66) KMT2AMEN1KDM4EGAAMAOB
SCHEMBL30970401 0.82 MAOB (0.66) KMT2AMEN1KDM4EGAAMAOB
SCHEMBL13704189 0.82 KMT2A (0.71) KMT2AMEN1KDM4EJUNABCG2
SCHEMBL27220196 0.82 KMT2A (0.68) KMT2AMEN1KDM4EGAAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2022-07-28 — — US claimed
US-12637409-B2 Styryl carboxylate derivatives Renovel Innovations, Inc. (US) 2026-05-26 — — US disclosed
US-20240317670-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2024-09-26 — — US disclosed
US-20240300883-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2024-09-12 — — US disclosed
US-11987551-B2 Styryl carboxylate derivatives Renovel Innovations, Inc. 2024-05-21 — — US disclosed
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2022-07-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES ACACB, ACACA, FABP7 KMT2A 1056/4885MEN1 4705/4885KDM4E 846/4885
US-20240300883-A1 STYRYL CARBOXYLATE DERIVATIVES SCD, ACACB, ACACA KMT2A 780/4885MEN1 4031/4885KDM4E 492/4885
US-20240317670-A1 STYRYL CARBOXYLATE DERIVATIVES ACACB, ACACA, GPR119 KMT2A 995/4885MEN1 4728/4885KDM4E 803/4885
US-12637409-B2 Styryl carboxylate derivatives GPR119, ACACB, ACACA KMT2A 778/4885MEN1 3737/4885KDM4E 580/4885
US-11987551-B2 Styryl carboxylate derivatives ACACB, ACACA, FABP7 KMT2A 1056/4885MEN1 4705/4885KDM4E 846/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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