SCHEMBL27220187

SCHEMBL27220187

COc1cccc(/C=C/C(=O)Oc2ccc(C=O)cc2OC)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NQO2 P16083 1/20 0.60
▸ KMT2A Q03164 3/20 0.56
▸ KDM4E B2RXH2 3/20 0.56
▸ ALDH1A1 P00352 2/20 0.56
▸ SMN1; SMN2 Q16637 2/20 0.56
▸ CYP1A2 P05177 1/20 0.55
▸ CYP3A4 P08684 1/20 0.55
▸ CYP2D6 P10635 1/20 0.55
▸ CYP2C9 P11712 1/20 0.55
▸ CYP2C19 P33261 1/20 0.55
▸ MEN1 O00255 1/20 0.55
▸ GAA P10253 1/20 0.55
▸ HTR1A P08908 1/20 0.53
▸ JUN P05412 2/20 0.52
▸ NFKB1 P19838 1/20 0.52
▸ PDE4A P27815 1/20 0.52
▸ PDE4B Q07343 1/20 0.52
▸ PDE4C Q08493 1/20 0.52
▸ PDE4D Q08499 1/20 0.52
▸ TTR P02766 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27220248 0.87 KMT2A (0.61) KMT2AKDM4EALDH1A1SMN1; SMN2MEN1
SCHEMBL7855954 0.87 KMT2A (0.61) KMT2AKDM4EALDH1A1SMN1; SMN2CYP1A2
SCHEMBL29823740 0.87 KMT2A (0.61) KMT2AKDM4EALDH1A1SMN1; SMN2CYP1A2
SCHEMBL7855955 0.87 KMT2A (0.61) KMT2AKDM4EALDH1A1SMN1; SMN2CYP1A2
SCHEMBL27220324 0.87 NQO2 (0.56) NQO2KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL27231520 0.87 NQO2 (0.56) NQO2KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL27220272 0.87 ALDH1A1 (0.54) KMT2AKDM4EALDH1A1SMN1; SMN2MEN1
SCHEMBL27220289 0.87 ALDH1A1 (0.52) KMT2AKDM4EALDH1A1SMN1; SMN2CYP1A2
SCHEMBL27220171 0.86 KMT2A (0.67) KMT2AKDM4ESMN1; SMN2CYP1A2CYP2D6
SCHEMBL14879574 0.84 EPHX2 (0.68) KMT2AKDM4EALDH1A1SMN1; SMN2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2022-07-28 — — US claimed
US-12637409-B2 Styryl carboxylate derivatives Renovel Innovations, Inc. (US) 2026-05-26 — — US disclosed
US-20240317670-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2024-09-26 — — US disclosed
US-20240300883-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2024-09-12 — — US disclosed
US-11987551-B2 Styryl carboxylate derivatives Renovel Innovations, Inc. 2024-05-21 — — US disclosed
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2022-07-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES ACACB, ACACA, FABP7 NQO2 3117/4885KMT2A 1056/4885KDM4E 846/4885
US-20240300883-A1 STYRYL CARBOXYLATE DERIVATIVES SCD, ACACB, ACACA NQO2 3786/4885KMT2A 780/4885KDM4E 492/4885
US-20240317670-A1 STYRYL CARBOXYLATE DERIVATIVES ACACB, ACACA, GPR119 NQO2 2792/4885KMT2A 995/4885KDM4E 803/4885
US-12637409-B2 Styryl carboxylate derivatives GPR119, ACACB, ACACA NQO2 2781/4885KMT2A 778/4885KDM4E 580/4885
US-11987551-B2 Styryl carboxylate derivatives ACACB, ACACA, FABP7 NQO2 3117/4885KMT2A 1056/4885KDM4E 846/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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