SCHEMBL27220388

SCHEMBL27220388

COc1cc(/C=N/O)ccc1OC(=O)/C=C/c1cccc(Br)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 5/20 0.51
▸ MEN1 O00255 1/20 0.51
▸ SMN1; SMN2 Q16637 8/20 0.49
▸ KDM4E B2RXH2 5/20 0.49
▸ ALDH1A1 P00352 4/20 0.49
▸ JUN P05412 1/20 0.48
▸ NFKB1 P19838 1/20 0.48
▸ MAPT P10636 4/20 0.48
▸ NPC1 O15118 2/20 0.47
▸ RAB9A P51151 2/20 0.47
▸ FDPS P14324 1/20 0.46
▸ HPGD P15428 1/20 0.46
▸ ALOX15 P16050 1/20 0.46
▸ MAPK1 P28482 1/20 0.46
▸ HSD17B10 Q99714 1/20 0.46
▸ HSD17B3 P37058 1/20 0.46
▸ PKM P14618 1/20 0.46
▸ JAK2 O60674 1/20 0.45
▸ GAA P10253 1/20 0.45
▸ HTT P42858 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27220144 1.00 KMT2A (0.51) KMT2AMEN1SMN1; SMN2KDM4EALDH1A1
SCHEMBL27220410 0.89 KMT2A (0.52) KMT2ASMN1; SMN2KDM4EALDH1A1JUN
SCHEMBL27220159 0.89 KMT2A (0.52) KMT2ASMN1; SMN2KDM4EALDH1A1JUN
SCHEMBL27231520 0.88 NQO2 (0.56) KMT2AMEN1SMN1; SMN2KDM4EALDH1A1
SCHEMBL27220324 0.88 NQO2 (0.56) KMT2AMEN1SMN1; SMN2KDM4EALDH1A1
SCHEMBL27220272 0.87 ALDH1A1 (0.54) KMT2AMEN1SMN1; SMN2KDM4EALDH1A1
SCHEMBL27220418 0.87 SMN1; SMN2 (0.54) KMT2AMEN1SMN1; SMN2KDM4EALDH1A1
SCHEMBL27220135 0.87 SMN1; SMN2 (0.54) KMT2AMEN1SMN1; SMN2KDM4EALDH1A1
SCHEMBL27220303 0.87 SMN1; SMN2 (0.54) KMT2AMEN1SMN1; SMN2KDM4EALDH1A1
SCHEMBL27220412 0.87 SMN1; SMN2 (0.49) KMT2AMEN1SMN1; SMN2KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2022-07-28 — — US claimed
US-12637409-B2 Styryl carboxylate derivatives Renovel Innovations, Inc. (US) 2026-05-26 — — US disclosed
US-20240317670-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2024-09-26 — — US disclosed
US-20240300883-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2024-09-12 — — US disclosed
US-11987551-B2 Styryl carboxylate derivatives Renovel Innovations, Inc. 2024-05-21 — — US disclosed
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2022-07-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES ACACB, ACACA, FABP7 KMT2A 1056/4885MEN1 4705/4885SMN1; SMN2 2759/4885
US-20240300883-A1 STYRYL CARBOXYLATE DERIVATIVES SCD, ACACB, ACACA KMT2A 780/4885MEN1 4031/4885SMN1; SMN2 3684/4885
US-20240317670-A1 STYRYL CARBOXYLATE DERIVATIVES ACACB, ACACA, GPR119 KMT2A 995/4885MEN1 4728/4885SMN1; SMN2 2950/4885
US-12637409-B2 Styryl carboxylate derivatives GPR119, ACACB, ACACA KMT2A 778/4885MEN1 3737/4885SMN1; SMN2 2149/4885
US-11987551-B2 Styryl carboxylate derivatives ACACB, ACACA, FABP7 KMT2A 1056/4885MEN1 4705/4885SMN1; SMN2 2759/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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