SCHEMBL27220272

SCHEMBL27220272

COc1cc(C=O)ccc1OC(=O)/C=C/c1cccc(Br)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 7/20 0.54
▸ SMN1; SMN2 Q16637 6/20 0.54
▸ KMT2A Q03164 3/20 0.53
▸ MEN1 O00255 1/20 0.53
▸ KDM4E B2RXH2 4/20 0.52
▸ JUN P05412 1/20 0.51
▸ NFKB1 P19838 1/20 0.51
▸ MAPT P10636 3/20 0.50
▸ FDPS P14324 1/20 0.49
▸ HPGD P15428 1/20 0.49
▸ ALOX15 P16050 1/20 0.49
▸ MAPK1 P28482 1/20 0.49
▸ HSD17B10 Q99714 1/20 0.49
▸ HSD17B3 P37058 1/20 0.49
▸ TSHR P16473 1/20 0.49
▸ PKM P14618 1/20 0.48
▸ JAK2 O60674 1/20 0.48
▸ GAA P10253 1/20 0.48
▸ HTT P42858 1/20 0.48
▸ NFE2L2 Q16236 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27220263 0.88 KMT2A (0.55) ALDH1A1SMN1; SMN2KMT2AKDM4EJUN
SCHEMBL27220144 0.87 KMT2A (0.51) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL27220388 0.87 KMT2A (0.51) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL27220187 0.87 NQO2 (0.60) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL29823740 0.86 KMT2A (0.61) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL7855954 0.86 KMT2A (0.61) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL7855955 0.86 KMT2A (0.61) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL27220289 0.86 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2KMT2AKDM4EJUN
SCHEMBL27220302 0.84 HTR1A (0.50) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E
SCHEMBL14879574 0.83 EPHX2 (0.68) ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2022-07-28 — — US claimed
US-12637409-B2 Styryl carboxylate derivatives Renovel Innovations, Inc. (US) 2026-05-26 — — US disclosed
US-20240317670-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2024-09-26 — — US disclosed
US-20240300883-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2024-09-12 — — US disclosed
US-11987551-B2 Styryl carboxylate derivatives Renovel Innovations, Inc. 2024-05-21 — — US disclosed
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2022-07-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES ACACB, ACACA, FABP7 ALDH1A1 313/4885SMN1; SMN2 2759/4885KMT2A 1056/4885
US-20240300883-A1 STYRYL CARBOXYLATE DERIVATIVES SCD, ACACB, ACACA ALDH1A1 369/4885SMN1; SMN2 3684/4885KMT2A 780/4885
US-20240317670-A1 STYRYL CARBOXYLATE DERIVATIVES ACACB, ACACA, GPR119 ALDH1A1 349/4885SMN1; SMN2 2950/4885KMT2A 995/4885
US-12637409-B2 Styryl carboxylate derivatives GPR119, ACACB, ACACA ALDH1A1 683/4885SMN1; SMN2 2149/4885KMT2A 778/4885
US-11987551-B2 Styryl carboxylate derivatives ACACB, ACACA, FABP7 ALDH1A1 313/4885SMN1; SMN2 2759/4885KMT2A 1056/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback