Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | TRPM5 | Q9NZQ8 | 2/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.40 |
| ▸ | TUBB | P07437 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722142 | 1.00 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3APPFFAR1 | |
| SCHEMBL7002288 | 0.86 | APP (0.55) | SLC6A2SLC6A4SLC6A3APPFFAR1 | |
| SCHEMBL7002284 | 0.86 | APP (0.55) | SLC6A2SLC6A4SLC6A3APPFFAR1 | |
| SCHEMBL2952559 | 0.86 | APP (0.55) | SLC6A2SLC6A4SLC6A3APPFFAR1 | |
| SCHEMBL7002924 | 0.84 | RXRA (0.49) | APPFFAR1CA1CA2CA9 | |
| SCHEMBL10254282 | 0.84 | RXRA (0.49) | APPFFAR1CA1CA2CA9 | |
| SCHEMBL6996736 | 0.82 | ALDH1A1 (0.52) | APPFFAR1CA1CA2CA9 | |
| SCHEMBL7000989 | 0.82 | KDM1A (0.61) | SLC6A2SLC6A4SLC6A3APPFFAR1 | |
| SCHEMBL6996735 | 0.82 | ALDH1A1 (0.52) | APPFFAR1CA1CA2CA9 | |
| SCHEMBL15669063 | 0.82 | KDM1A (0.61) | SLC6A2SLC6A4SLC6A3APPFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632269-A1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058187-A1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |