Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996736 | 1.00 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2AAPPFFAR1 | |
| SCHEMBL7002284 | 0.86 | APP (0.55) | KMT2AAPPFFAR1CA1CA2 | |
| SCHEMBL2952559 | 0.86 | APP (0.55) | KMT2AAPPFFAR1CA1CA2 | |
| SCHEMBL7002288 | 0.86 | APP (0.55) | KMT2AAPPFFAR1CA1CA2 | |
| SCHEMBL7002924 | 0.84 | RXRA (0.49) | APPFFAR1CA1CA2CA9 | |
| SCHEMBL10254282 | 0.84 | RXRA (0.49) | APPFFAR1CA1CA2CA9 | |
| SCHEMBL2722140 | 0.82 | SLC6A2 (0.50) | KMT2AAPPFFAR1CA1CA2 | |
| SCHEMBL2722142 | 0.82 | SLC6A2 (0.50) | KMT2AAPPFFAR1CA1CA2 | |
| SCHEMBL7000989 | 0.82 | KDM1A (0.61) | APPFFAR1CA1CA2CA9 | |
| SCHEMBL15669063 | 0.82 | KDM1A (0.61) | APPFFAR1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996621-B1 | TRIAZOLO[4,5-d]PYRIMIDINE DERIVATIVES AS ANTI-THROMBOTIC AGENTS | ASTRAZENECA AB (SE) | 2003-10-01 | — | — | EP | disclosed |
| US-6251910-B1 | 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists | ASTRAZENECA UK LIMITED (GB) | 2001-06-26 | — | — | US | disclosed |