Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29409552 | 0.78 | KIF11 (0.44) | HTTHDAC1HDAC7HDAC8 | |
| SCHEMBL5983235 | 0.76 | NPC1 (0.48) | MAPTHPGDTDP1ACHEMEN1 | |
| SCHEMBL3786178 | 0.76 | MAPT (0.44) | MAPTACHEMEN1KMT2ALMNA | |
| SCHEMBL1248173 | 0.74 | TDP1 (0.44) | MAPTHPGDTDP1ACHEMEN1 | |
| SCHEMBL28444452 | 0.74 | MAPT (0.42) | MAPTHPGDMEN1KMT2ALMNA | |
| SCHEMBL6313165 | 0.74 | MAPT (0.42) | MAPTHPGDTDP1MEN1KMT2A | |
| SCHEMBL3651020 | 0.74 | POLB (0.44) | MAPTTDP1MEN1KMT2ALMNA | |
| SCHEMBL6325751 | 0.73 | GAA (0.56) | MAPTHPGDTDP1ACHEMEN1 | |
| SCHEMBL412378 | 0.72 | ALDH1A1 (0.45) | MAPTHPGDTDP1MEN1KMT2A | |
| SCHEMBL11296546 | 0.72 | CYP1A2 (0.57) | MAPTHPGDACHEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767297-B2 | Compounds for inhibiting TNIK and medical uses thereof | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2023-09-26 | — | — | US | disclosed |
| WO-2023097195-A1 | THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |
| US-20230039679-A1 | COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2023-02-09 | — | — | US | disclosed |
| WO-2021044478-A1 | IONIC COMPOUND, ORGANIC ELECTRONICS MATERIAL, ORGANIC LAYER, ORGANIC ELECTRONICS ELEMENT, ORGANIC ELECTROLUMINESCENT ELEMENT, DISPLAY ELEMENT, LIGHTING DEVICE, AND METHOD FOR MANUFACTURING ORGANIC ELECTRONICS ELEMENT | 昭和電工マテリアルズ株式会社 | 2021-03-11 | — | — | WO | disclosed |
| US-20210047277-A1 | COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2021-02-18 | — | — | US | disclosed |
| WO-2019156439-A1 | COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2019-08-15 | — | — | WO | disclosed |
| EP-3348547-A1 | NOVEL BENZIMIDAZOLE COMPOUND AND PHARMACEUTICAL USE OF SAME | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2018-07-18 | — | — | EP | disclosed |
| EP-2727947-B1 | COPOLYMER, AND LIQUID CRYSTAL ALIGNMENT LAYER COMPRISING HARDENED PRODUCT THEREOF | DAINIPPON INK & CHEMICALS (JP) | 2017-03-15 | — | — | EP | disclosed |
| EP-3121167-A1 | COMPOUND BINDING TO PPARG BUT NOT ACTING AS PROMOTER AND PHARMACEUTICAL COMPOSITION FOR TREATING PPARG-RELATED DISEASES CONTAINING SAME AS ACTIVE INGREDIENT | Hyundai Pharm Co., Ltd. (KR) | 2017-01-25 | — | — | EP | disclosed |
| WO-2012054862-A2 | AGENTS, COMPOSITIONS, AND METHODS FOR TREATING PRURITIS AND RELATED SKIN CONDITIONS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| US-6359009-B1 | IN PARTICULAR, SOIL-DWELLING COLEOPTERA; CROPS | BASF AKTIENGESELLSCHAFT | 2002-03-19 | — | — | US | disclosed |
| US-5886223-A | REACTING A SUBSTITUTED ANILINE COMPOUND WITH A TETRAALKYL-1,3-CYCLOBUTANEDIONE COMPOUND AND A BASE IN THE PRESENCE OF A SOLVENT | AMERICAN CYANAMID COMPANY (US) | 1999-03-23 | — | — | US | disclosed |
| EP-0475676-B1 | Electrophotographic member | HITACHI CHEMICAL CO LTD (JP) | 1996-04-03 | — | — | EP | disclosed |
| US-5403958-A | Fluoroalkoxy-substituted diarylamines as intermediates for charge transfer compounds | HITACHI CHEMICAL CO., LTD. (JP) | 1995-04-04 | — | — | US | disclosed |
| US-5352834-A | Fluorine-containing N,N,N*,N*-tetraarylbenzidine derivative as charge transport material for electrography | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1994-10-04 | — | — | US | disclosed |
| US-5160487-A | Tetraarylbenzidine derivative as charge transport compound | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1992-11-03 | — | — | US | disclosed |
| EP-0475676-A1 | Electrophotographic member | HITACHI CHEMICAL CO., LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11767297-B2 | Compounds for inhibiting TNIK and medical uses thereof | TNNI3K, TNK1, TNIK | MAPT 3588/4885HPGD 1068/4885TDP1 1047/4885 |
| US-20210047277-A1 | COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF | TNNI3K, TNK1, TNIK | MAPT 3588/4885HPGD 1068/4885TDP1 1047/4885 |
| US-20230039679-A1 | COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF | TNNI3K, TNK1, TNIK | MAPT 3588/4885HPGD 1068/4885TDP1 1047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.