Adamantane

Adamantane

SCHEMBL27239

C1C2CC3CC1CC(C2)C3.CC(=O)O

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Adamantane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB4 known ✓ P30926 1/20 0.39
CHRNA3 known ✓ P32297 1/20 0.39
FFAR3 O14843 1/20 0.54
LCK P06239 1/20 0.54
FYN P06241 1/20 0.54
HSD11B1 P28845 2/20 0.43
TSHR P16473 2/20 0.42
CHRNB2 P17787 1/20 0.39
CHRNA7 P36544 1/20 0.39
CHRNA4 P43681 1/20 0.39
CYP2C9 P11712 2/20 0.37
LMNA P02545 3/20 0.36
CYP2D6 P10635 2/20 0.35
BLM P54132 2/20 0.35
THRB P10828 2/20 0.35
ALOX15 P16050 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C19 P33261 1/20 0.35
RAB9A P51151 1/20 0.35
MEN1 O00255 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Adamantane SCHEMBL8402827 1.00 FFAR3 (0.54) FFAR3LCKFYNHSD11B1TSHR
Adamantane SCHEMBL28005909 0.88 LMNA (0.50) FFAR3LCKFYNHSD11B1TSHR
Acetic Acid SCHEMBL14244268 0.86 FFAR3 (0.47) FFAR3LCKFYNHSD11B1TSHR
Adamantane SCHEMBL7710713 0.85 CHRNB2 (0.39) HSD11B1TSHRCHRNB2CHRNB4CHRNA3
Adamantane SCHEMBL974954 0.84 HSD11B1 (0.48) HSD11B1TSHRCYP2C9LMNACYP2D6
Adamantane SCHEMBL3981833 0.84 HSD11B1 (0.48) HSD11B1TSHRCYP2C9LMNACYP2D6
Adamantane SCHEMBL935449 0.84 HSD11B1 (0.48) HSD11B1TSHRCYP2C9LMNACYP2D6
Adamantane SCHEMBL14841654 0.81 LMNA (0.57) HSD11B1TSHRCHRNB2CHRNB4CHRNA3
Adamantane SCHEMBL10365099 0.81 CHRNB2 (0.37) HSD11B1TSHRCHRNB2CHRNB4CHRNA3
Adamantane SCHEMBL131439 0.81 TDP1 (0.38) FFAR3LCKFYNHSD11B1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 14251 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119823115-B Compound for degrading Pol theta based on hydrophobic tag and preparation method and application thereof CHINA PHARMACEUTICAL UNIVERSITY (CN) 2026-05-26 CN claimed
WO-2026090085-A1 TREATMENT OF CD33 RELATED DISEASES AND DISORDERS EMPIRICO INC. (US) 2026-04-30 WO claimed
US-12565653-B2 ATAXIN3 (ATXN3) RNAi agent compositions and methods of use thereof ALNYLAM PHARMACEUTICALS, INC. (US) 2026-03-03 US claimed
US-12553053-B2 Transmembrane serine protease 2 (TMPRSS2) iRNA compositions and methods of use thereof ALNYLAM PHARMACEUTICALS, INC. (US) 2026-02-17 US claimed
US-12534731-B2 Alpha-2A adrenergic receptor (ADRA2A) iRNA agent compositions and methods of use thereof ALNYLAM PHARMACEUTICALS, INC. (US) 2026-01-27 US claimed
EP-4627082-A1 TREATMENT OF MTRES1 RELATED DISEASES AND DISORDERS EMPIRICO INC. (US) 2025-10-08 EP claimed
US-20250283079-A1 ACTIN-BINDING LIM PROTEIN 3 (ABLIM3) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2025-09-11 US claimed
US-12391945-B2 Coronavirus IRNA compositions and methods of use thereof ALNYLAM PHARMACEUTICALS, INC. (US) 2025-08-19 US claimed
EP-4594492-A1 MODIFIED DOUBLE-STRANDED RNA AGENTS Alnylam Pharmaceuticals, Inc. (US) 2025-08-06 EP claimed
US-12378553-B2 Modified double-stranded RNA agents ALNYLAM PHARMACEUTICALS, INC. (US) 2025-08-05 US claimed
US-20020039741-A1 Antitumor agent DEAN NICHOLAS M (US) 2002-04-04 US claimed
EP-0957926-A4 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF THE EXPRESSION OF B7 PROTEIN ISIS PHARMACEUTICALS INC (US) 2002-01-23 EP claimed
US-6319906-B1 FOR THERAPY OF AUTOIMMUNE DISEASE, INFLAMMATORY DISEASE, FOR INHIBITING ALLOGRAFT REJECTION ISIS PHARMACEUTICALS 2001-11-20 US claimed
US-6312900-B1 FOR MODULATING METASTASIS OF MALIGNANT TUMORS VIA MODULATION OF ACTIVATING PROTEIN 1 ISIS PHARMACEUTICALS, INC. 2001-11-06 US claimed
JP-2000507833-A 2000-06-27 JP claimed
US-6077833-A FOR DIAGNOSIS, PREVENTION AND TREATMENT OF IMMUNE STATES AND DISORDERS AMENABLE TO TREATMENT THROUGH MODULATION OF T CELL ACTIVATION SUCH AS FOR PREVENTING ALLOGRAFT REJECTION ISIS PHARMACEUTICALS, INC. (US) 2000-06-20 US claimed
US-6001991-A NUCLEOTIDE SEQUENCES WHICH HYBRIDIZE TO AND SUPPRESS EXPRESSION OF MULTIDRUG RESISTANCE GENE; FOR PREVENTING OR MODULATING THE DEVELOPMENT OF MULTIDRUG RESISTANCE DURING CHEMOTHERAPEUTIC TREATMENT OR RESENSITIZING TREATED CELLS ISIS PHARMACEUTICALS INC. (US) 1999-12-14 US claimed
EP-0957926-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF THE EXPRESSION OF B7 PROTEIN ISIS PHARMACEUTICALS, INC. (US) 1999-11-24 EP claimed
WO-1998029124-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF THE EXPRESSION OF B7 PROTEIN ISIS PHARMACEUTICALS, INC. (US) 1998-07-09 WO claimed
WO-1998014615-A1 ANTISENSE OLIGONUCLEOTIDE MODULATION OF MDR P-GLYCOPROTEIN GENE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 1998-04-09 WO claimed