Sugi Predict

Sugi Predict / Compounds / SCHEMBL2724360

SCHEMBL2724360

SCHEMBL2724360

C=CCc1cc(C)cc(-n2nc3ccc(Cl)cc3n2)c1O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 5/20 0.49
▸ RAB9A P51151 4/20 0.49
▸ POLB P06746 1/20 0.39
▸ LMNA P02545 1/20 0.37
▸ GAA P10253 1/20 0.34
▸ KDM4E B2RXH2 3/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ MAPT P10636 3/20 0.34
▸ TP53 P04637 1/20 0.34
▸ MEN1 O00255 3/20 0.33
▸ KMT2A Q03164 3/20 0.33
▸ PTGDR Q13258 1/20 0.33
▸ PTGDR2 Q9Y5Y4 1/20 0.33
▸ ALOX5 P09917 2/20 0.33
▸ PTGS1 P23219 1/20 0.33
▸ PTGS2 P35354 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7166175 0.87 NPC1 (0.36) NPC1RAB9APOLBLMNAGAA
SCHEMBL285279 0.86 NPC1 (0.58) NPC1RAB9APOLBLMNAGAA
SCHEMBL15910157 0.86 NPC1 (0.55) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL29384819 0.86 NPC1 (0.58) NPC1RAB9APOLBLMNAGAA
SCHEMBL5697093 0.85 NPC1 (0.53) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL2146927 0.85 NPC1 (0.53) NPC1RAB9APOLBLMNAGAA
SCHEMBL9408785 0.84 NPC1 (0.52) NPC1RAB9APOLBLMNAGAA
SCHEMBL196019 0.82 NPC1 (0.50) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL29401488 0.82 NPC1 (0.50) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL1532693 0.81 NPC1 (0.49) NPC1RAB9APOLBLMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109641831-B Monomers, polymers, preparation method and use thereof 东莞东阳光医疗智能器件研发有限公司 2021-09-10 — — CN disclosed
US-9447123-B2 Process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds; use of the said compounds obtained via the process in the synthesis of siloxane compounds containing a 2-hydroxyphenylbenzotriazole function L'OREAL (FR) 2016-09-20 — — US disclosed
US-9447123-B2 Process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds; use of the said compounds obtained via the process in the synthesis of siloxane compounds containing a 2-hydroxyphenylbenzotriazole function L'OREAL (FR) 2016-09-20 — — US disclosed
US-9447123-B2 Process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds; use of the said compounds obtained via the process in the synthesis of siloxane compounds containing a 2-hydroxyphenylbenzotriazole function L'OREAL (FR) 2016-09-20 — — US disclosed
EP-2632904-B1 PROCESS FOR PREPARING 2-HYDROXYPHENYL ALKENYL BENZOTRIAZOLE COMPOUNDS AND PROCESS FOR PREPARING SILOXANE COMPOUNDS CONTAINING 2-HYDROXYPHENYL BENZOTRIZOLE FUNCTION ORÉAL L (FR) 2016-03-23 — — EP disclosed
EP-2632904-B1 PROCESS FOR PREPARING 2-HYDROXYPHENYL ALKENYL BENZOTRIAZOLE COMPOUNDS AND PROCESS FOR PREPARING SILOXANE COMPOUNDS CONTAINING 2-HYDROXYPHENYL BENZOTRIZOLE FUNCTION ORÉAL L (FR) 2016-03-23 — — EP disclosed
US-20130231488-A1 PROCESS FOR PREPARING 2-HYDROXYPHENYL ALKENYL BENZOTRIAZOLE COMPOUNDS; USE OF THE SAID COMPOUNDS OBTAINED VIA THE PROCESS IN THE SYNTHESIS OF SILOXANE COMPOUNDS CONTAINING A 2-HYDROXYPHENYLBENZOTRIAZOLE FUNCTION L'OREAL (FR) 2013-09-05 — — US disclosed
US-20130231488-A1 PROCESS FOR PREPARING 2-HYDROXYPHENYL ALKENYL BENZOTRIAZOLE COMPOUNDS; USE OF THE SAID COMPOUNDS OBTAINED VIA THE PROCESS IN THE SYNTHESIS OF SILOXANE COMPOUNDS CONTAINING A 2-HYDROXYPHENYLBENZOTRIAZOLE FUNCTION L'OREAL (FR) 2013-09-05 — — US disclosed
US-20130231488-A1 PROCESS FOR PREPARING 2-HYDROXYPHENYL ALKENYL BENZOTRIAZOLE COMPOUNDS; USE OF THE SAID COMPOUNDS OBTAINED VIA THE PROCESS IN THE SYNTHESIS OF SILOXANE COMPOUNDS CONTAINING A 2-HYDROXYPHENYLBENZOTRIAZOLE FUNCTION L'OREAL (FR) 2013-09-05 — — US disclosed
EP-2632904-A1 PROCESS FOR PREPARING 2-HYDROXYPHENYL ALKENYL BENZOTRIAZOLE COMPOUNDS AND PROCESS FOR PREPARING SILOXANE COMPOUNDS CONTAINING 2-HYDROXYPHENYL BENZOTRIZOLE FUNCTION L'Oréal (FR) 2013-09-04 — — EP disclosed
WO-2012055063-A1 PROCESS FOR PREPARING 2-HYDROXYPHENYL ALKENYL BENZOTRIAZOLE COMPOUNDS AND PROCESS FOR PREPARING SILOXANE COMPOUNDS CONTAINING 2-HYDROXYPHENYL BENZOTRIZOLE FUNCTION L'OREAL (FR) 2012-05-03 — — WO disclosed
WO-2012055063-A1 PROCESS FOR PREPARING 2-HYDROXYPHENYL ALKENYL BENZOTRIAZOLE COMPOUNDS AND PROCESS FOR PREPARING SILOXANE COMPOUNDS CONTAINING 2-HYDROXYPHENYL BENZOTRIZOLE FUNCTION L'OREAL (FR) 2012-05-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130231488-A1 PROCESS FOR PREPARING 2-HYDROXYPHENYL ALKENYL BENZOTRIAZOLE COMPOUNDS; USE OF THE SAID COMPOUNDS OBTAINED VIA THE PROCESS IN THE SYNTHESIS OF SILOXANE COMPOUNDS CONTAINING A 2-HYDROXYPHENYLBENZOTRIAZOLE FUNCTION HPD, PAH, SULT2A1 NPC1 3298/4885RAB9A 4798/4885POLB 405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.