Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.55 |
| ▸ | TUBB | P07437 | 1/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.55 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.55 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.55 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.55 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.55 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.55 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.55 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.55 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.55 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722449 | 0.93 | EGFR (0.63) | EGFRPDGFRBTUBB4ATUBBTUBA3C | |
| SCHEMBL8649255 | 0.84 | EGFR (0.68) | EGFRPDGFRBTUBB4ATUBBTUBA3C | |
| SCHEMBL8081981 | 0.83 | EGFR (0.55) | EGFRPDGFRBTUBB4ATUBBTUBA3C | |
| SCHEMBL8646018 | 0.82 | TUBB4A (0.76) | EGFRPDGFRBTUBB4ATUBBTUBA3C | |
| SCHEMBL4719788 | 0.79 | EGFR (0.87) | EGFRPDGFRBTUBB4ATUBBTUBA3C | |
| Hydrochloric Acid SCHEMBL6180077 | 0.78 | EGFR (0.87) | EGFRPDGFRBTUBB4ATUBBTUBA3C | |
| SCHEMBL10072046 | 0.77 | NUDT1 (0.42) | EGFRPDGFRBTUBB4ATUBBTUBA3C | |
| SCHEMBL4717907 | 0.75 | EGFR (0.85) | EGFRPDGFRBTUBB4ATUBBTUBA3C | |
| SCHEMBL2730641 | 0.75 | KDM4E (0.49) | PDGFRBKDM4EMAPTHPGDRAB9A | |
| SCHEMBL2725752 | 0.75 | PDGFRB (0.48) | PDGFRBKDM4EHPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006255-B2 | Quinazoline derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006255-B2 | Quinazoline derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006255-B2 | Quinazoline derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| EP-2632923-B1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2632923-B1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2632923-A1 | QUINAZOLINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-09-04 | — | — | EP | disclosed |
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| CN-103153997-A | Quinazoline derivatives | MERCK PATENT GMBH | 2013-06-12 | — | — | CN | disclosed |
| WO-2012055466-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-05-03 | — | — | WO | disclosed |
| WO-2012055466-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | RAB1A, PIK3R5, PIK3R1 | EGFR 2305/4885PDGFRB 2288/4885TUBB4A 2176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.