Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10072044 | 0.87 | EGFR (0.44) | NUDT1PTK2EGFRPDGFRBCYP2C19 | |
| SCHEMBL2722449 | 0.79 | EGFR (0.63) | EGFRPDGFRBALDH1A1CSF1RHSD17B10 | |
| SCHEMBL2725484 | 0.77 | EGFR (0.55) | EGFRPDGFRBALDH1A1MAPK1CSF1R | |
| SCHEMBL25888835 | 0.70 | NOTUM (0.44) | NUDT1TSHRPIK3CACYP1A2LMNA | |
| SCHEMBL1585491 | 0.69 | HTT (0.51) | PTK2PDGFRBCYP2C19ALDH1A1MAPK1 | |
| SCHEMBL4178072 | 0.69 | PRKDC (0.52) | PTK2PDGFRBCYP2C19ALDH1A1MAPK1 | |
| SCHEMBL3805071 | 0.69 | LMNA (0.54) | ALDH1A1MAPK1TSHRLMNAMEN1 | |
| SCHEMBL2725752 | 0.69 | PDGFRB (0.48) | PTK2PDGFRBCYP2C19ALDH1A1MAPK1 | |
| SCHEMBL1734528 | 0.68 | PRKDC (0.53) | PTK2PDGFRBCYP2C19ALDH1A1MAPK1 | |
| SCHEMBL2730641 | 0.67 | KDM4E (0.49) | PTK2PDGFRBCYP2C19ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006255-B2 | Quinazoline derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006255-B2 | Quinazoline derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006255-B2 | Quinazoline derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| EP-2632923-B1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-01-14 | — | — | EP | disclosed |
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| WO-2012055466-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | RAB1A, PIK3R5, PIK3R1 | NUDT1 2669/4885PTK2 996/4885EGFR 2305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.