Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Aminothiazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 known ✓ | P29475 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminothiazole SCHEMBL1003511 | 0.92 | ALDH1A1 (0.68) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL4466019 | 0.92 | ALDH1A1 (0.68) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL28215372 | 0.90 | ALDH1A1 (0.65) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL5907075 | 0.90 | ALDH1A1 (0.65) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL10585434 | 0.86 | ALDH1A1 (0.71) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL1241596 | 0.83 | ALDH1A1 (0.75) | ALDH1A1TSHRNOS1HSD17B10NPC1 | |
| Aminothiazole SCHEMBL28380726 | 0.82 | ALDH1A1 (0.65) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL27899272 | 0.81 | — | — | |
| Aminothiazole SCHEMBL5907076 | 0.80 | ALDH1A1 (0.62) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL28006118 | 0.80 | ALDH1A1 (0.62) | ALDH1A1TSHRNOS1HSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1269776-C | Process for producing carboxylic acid derivative and condensing agent comprising quaternary ammonium salt | TOKUYAMA CORP (JP) | 2006-08-16 | — | — | CN | claimed |
| CN-1304392-A | Process for producing carboxylic acid derivative and condensing agent comprising quaternary ammonium salt | TOKUYAMA CORP (JP) | 2001-07-18 | — | — | CN | claimed |
| CN-1045297-C | A method for the acylation of the 7-amino group of the cephalosporanic ring | FINPAEL SPA (IT) | 1999-09-29 | — | — | CN | claimed |
| CN-1082610-A | The method of the 7-amino on the acidylate cephalonic acid ring | FINPAEL SPA (IT) | 1994-02-23 | — | — | CN | claimed |
| CN-109232609-A | A method of preparing high-purity Cefpodoxime Proxetil | 浙江普洛得邦制药有限公司 | 2019-01-18 | — | — | CN | disclosed |
| CN-1269776-C | Process for producing carboxylic acid derivative and condensing agent comprising quaternary ammonium salt | TOKUYAMA CORP (JP) | 2006-08-16 | — | — | CN | disclosed |
| CN-1196686-C | Method for storing quaternary ammonium salt | TOKUYAMA CORP (JP) | 2005-04-13 | — | — | CN | disclosed |
| CN-1160361-C | Method for prepairng highly purity cefpodoxime proxetil | ����ҩƷ��ҵ��ʽ���� | 2004-08-04 | — | — | CN | disclosed |
| CN-1387533-A | Method for prepairng highly purity cefpodoxime proxetil | HANMI PHARM IND CO LTD (KR) | 2002-12-25 | — | — | CN | disclosed |
| CN-1372554-A | Method for preserving quaternary ammonium salts | TOKUYAMA CORP (JP) | 2002-10-02 | — | — | CN | disclosed |
| CN-1304392-A | Process for producing carboxylic acid derivative and condensing agent comprising quaternary ammonium salt | TOKUYAMA CORP (JP) | 2001-07-18 | — | — | CN | disclosed |
| CN-1059438-C | Method for preparing cynnematin antibiotic | BRISTOL MYERS SQUIBB CO (US) | 2000-12-13 | — | — | CN | disclosed |
| CN-1158333-A | Method for preparing cynnematin antibiotic | BRISTOL MYERS SQUIBB CO (US) | 1997-09-03 | — | — | CN | disclosed |
| CN-1140714-A | Preparation of cephalosporin antibiotic using syn-isomer of thiazolyl intermediate | BRISTOL MYERS SQUIBB CO (US) | 1997-01-22 | — | — | CN | disclosed |
| CN-1025195-C | Cephalosporin derivatives and their production and uses | MEIJI SEIKA KAISHA LED (JP) | 1994-06-29 | — | — | CN | disclosed |
| CN-1082610-A | The method of the 7-amino on the acidylate cephalonic acid ring | FINPAEL SPA (IT) | 1994-02-23 | — | — | CN | disclosed |
| CN-1082610-A | The method of the 7-amino on the acidylate cephalonic acid ring | FINPAEL SPA (IT) | 1994-02-23 | — | — | CN | disclosed |
| CN-1070406-A | Preparation of cephalosporin antibiotics using cis isomer of thiazolyl intermediate | BRISTOL MYERS SQUIBB CO (US) | 1993-03-31 | — | — | CN | disclosed |
| CN-1070398-A | Process for preparing cephalosporin antibiotics | BRISTOL MYERS SQUIBB CO (US) | 1993-03-31 | — | — | CN | disclosed |
| CN-1052309-A | Cephalosporins derivatives and preparation thereof and application | MEIJI SEIKA KAISHA (JP) | 1991-06-19 | — | — | CN | disclosed |