Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Aminothiazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 known ✓ | P29475 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminothiazole SCHEMBL4466019 | 0.98 | ALDH1A1 (0.68) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL1003511 | 0.98 | ALDH1A1 (0.68) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL5907075 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL10585434 | 0.91 | ALDH1A1 (0.71) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL27261063 | 0.90 | ALDH1A1 (0.58) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL28006118 | 0.89 | ALDH1A1 (0.62) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL28380726 | 0.87 | ALDH1A1 (0.65) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL27899272 | 0.86 | — | — | |
| Aminothiazole SCHEMBL5907076 | 0.85 | ALDH1A1 (0.62) | ALDH1A1TSHRNOS1HSD17B10HTT | |
| Aminothiazole SCHEMBL1241596 | 0.84 | ALDH1A1 (0.75) | ALDH1A1TSHRNOS1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107964558-B | Preparation method of cefotiam hydrochloride impurity destetrazolium cefotiam | 河北九派制药股份有限公司 | 2021-09-03 | — | — | CN | claimed |
| CN-109336906-B | Drying process of cefotiam hydrochloride | 山东罗欣药业集团股份有限公司 | 2020-05-22 | — | — | CN | claimed |
| CN-107987091-A | A kind of preparation method of cefotiam hydrochloride impurity 3- methyl cefotiam chlorides | 河北九派制药股份有限公司 | 2018-05-04 | — | — | CN | claimed |
| CN-107964558-A | A kind of cefotiam hydrochloride impurity takes off the preparation method of tetrazole Cefotiam | 河北九派制药股份有限公司 | 2018-04-27 | — | — | CN | claimed |
| CN-107964558-B | Preparation method of cefotiam hydrochloride impurity destetrazolium cefotiam | 河北九派制药股份有限公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-109517002-B | Synthesis method of cefotiam hydrochloride | 山东罗欣药业集团股份有限公司 | 2020-06-09 | — | — | CN | disclosed |
| CN-109336906-B | Drying process of cefotiam hydrochloride | 山东罗欣药业集团股份有限公司 | 2020-05-22 | — | — | CN | disclosed |
| CN-109517002-A | A kind of synthetic method of cefotiam hydrochloride | 山东罗欣药业集团股份有限公司 | 2019-03-26 | — | — | CN | disclosed |
| CN-109134506-A | One water cefotiam hydrochloride compound of one kind and its pharmaceutical composition | 宁应 | 2019-01-04 | — | — | CN | disclosed |
| CN-109134506-A | One water cefotiam hydrochloride compound of one kind and its pharmaceutical composition | 宁应 | 2019-01-04 | — | — | CN | disclosed |
| CN-107987091-A | A kind of preparation method of cefotiam hydrochloride impurity 3- methyl cefotiam chlorides | 河北九派制药股份有限公司 | 2018-05-04 | — | — | CN | disclosed |
| CN-107964558-A | A kind of cefotiam hydrochloride impurity takes off the preparation method of tetrazole Cefotiam | 河北九派制药股份有限公司 | 2018-04-27 | — | — | CN | disclosed |